Adenocarcinoma of Ethmoid: A GETTEC Retrospective Multicenter Study of 418 Cases
Adenocarcinoma of Ethmoid: A GETTEC Retrospective Multicenter Study of 418 Cases
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DOI：
10.1097/mlg.0b013e31815b48e3
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发表时间：
2008-03-01
期刊：
影响因子：
2.6
通讯作者：
Dehesdin, Daniele
中科院分区：
文献类型：
--
作者：
Choussy, Olivier;Ferron, Christophe;Dehesdin, Daniele
目的：探讨筛窦腺癌的危险因素及治疗方法。材料与方法：多中心回顾性研究。从1976年至2001年，418例患者提出了与筛窦腺癌在11家法国医院的医疗记录进行了分析，以确定临床特点和治疗的疾病。毒性暴露是这种病变的典型表现，大多数情况下暴露于木材和皮革。平均年龄为63岁（范围31-91岁）。症状是非特异性的，基于临床病理学体征。鼻内窥镜检查后粘膜回缩被发现有用的评估病变的扩展和进行活检。治疗前必须进行计算机断层扫描和磁共振成像，以确定额外的鼻延伸。存活率受病变大小（T4，N+）和向脑或硬脑膜的延伸的显著影响。手术加术后放疗仍是治疗的首选。全切除必须是一个主要的优先事项，在我们的series.Conclusion证实：这项回顾性研究是，据我们所知，有史以来最大的文献报道。该系列证实了该病变的风险因素以及病变对生存率的影响。手术是治疗中最重要的部分。局部复发是预后不良的原因。
Objective: To determine risk factors and evaluate the treatment of ethmoid adenocarcinoma. Epidemiologic data were recorded and compared with the literature.Materials and Methods: A multicenter and retrospective study. The medical records of 418 patients who had presented with ethmoid adenocarcinoma at 11 French hospitals from 1976 to 2001 were analyzed to determine the clinical characteristics and treatment of the disease.Results: The gender ratio was 2.8 men per 1 woman. Toxic exposure was classic for this lesion, exposure to wood and leather for most cases. The mean age was 63 years (range 31-91). Symptoms were nonspecific and based on clinical rhinologic signs. Nasal endoscopy after mucosal retraction was found useful to evaluate the extension of the lesion and to perform biopsies. Computed tomography scan and magnetic resonance imagery must be carried out prior to treatment to define extra nasal extension. The survival rate was significantly influenced by the size of the lesion (T4, N+) and extension to brain or dura. Surgery with postoperative radiotherapy remains the treatment of choice. Total excision must be a major priority, as confirmed in our series.Conclusion: This retrospective study was, to our knowledge, the largest ever reported in the literature. This series confirmed the risk factor of this lesion as well as the lesion's influence on the survival rate. Surgery is the most important part of the treatment. Local recurrences were responsible for the poor prognosis of this lesion.