Antecedent treatment with different antibiotic agents as a risk factor for vancomycin-resistant enterococcus
Antecedent treatment with different antibiotic agents as a risk factor for vancomycin-resistant enterococcus
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DOI：
10.3201/eid0808.010418
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发表时间：
2002-08-01
影响因子：
11.8
通讯作者：
Samore, MH
中科院分区：
文献类型：
--
作者：
Carmeli, Y;Eliopoulos, GM;Samore, MH
We conducted a matched case-control study to compare the effect of antecedent treatment with various antibiotics on subsequent isolation of vancomycin-resistant Enterococcus (VRE); 880 in-patients; 233 VRE cases, and 647 matched controls were included. After being matched for hospital location, calendar time, and duration of hospitalization, the following variables predicted VRE positivity: main admitting diagnosis; a coexisting condition (e.g., diabetes mellitus, organ transplant, or hepatobiliary disease); and infection or colonization with methicillin-resistant Staphylococcus aureus or Clostridium difficile within the past year (independent of vancomycin treatment). After controlling for these variables, we examined the effect of various antibiotics. Intravenous treatment with third-gene ration cephalosporins, metronidazole, and fluoroquinolones was positively associated with VRE. In our institution, when we adjusted the data for temporospatial factors, patient characteristics, and hospital events, treatment with third-generation cephalosporins, metronidazole, and fluoroquinolones was identified as a risk factor for VRE. Vancomycin was not a risk factor for isolation of VRE.
