One-pot synthesis of polypyrrole nanoparticles with tunable photothermal conversion and drug loading capacity
One-pot synthesis of polypyrrole nanoparticles with tunable photothermal conversion and drug loading capacity
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一锅法合成光热转换和载药量可调的聚吡咯纳米粒子
DOI：
10.1016/j.colsurfb.2019.02.016
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发表时间：
2019-05-01
影响因子：
5.8
通讯作者：
Wang, Shige
中科院分区：
文献类型：
--
作者：
Guo, Bingqian;Zhao, Jiulong;Wang, Shige
聚吡咯（PPy）纳米粒子具有优异的近红外（NIR）光响应特性，已成为一种很有前途的用于肿瘤光热治疗（PTT）的近红外光热转换剂。在此，我们报道了聚乙烯吡咯烷酮（PVP）介导的一锅法合成具有胶体稳定性和生物相容性的聚吡咯纳米粒子（PPy - PVP NPs），用于肿瘤的光热 - 化学联合治疗。我们系统地研究了分子量和PVP浓度对所得PPy - PVP NPs的光谱特性、光热特性、载药性能和抗肿瘤效率的影响。通过在合成过程中选择分子量为360 kDa（浓度为5 mg/mL）的PVP作为模板和表面改性剂，合成了具有最佳光谱特性、光热特性、载药性能和抗肿瘤效率的PPy - PVP NPs。本研究的结果有望深入理解表面工程在聚吡咯纳米粒子的合理设计和生物医学应用中的重要特性。
With an excellent near-infrared (MR) light-responsive property, polypyrrole (PPy) nanoparticle has emerged as a promising NIR photothermal transducing agent for tumor photothermal therapy (PTT). Herein, we reported the PVP mediated one-pot synthesis of colloidal stable and biocompatible PPy nanoparticles (PPy-PVP NPs) for combined tumor photothermal-chemotherapy. The influence of molecular weight and PVP concentration on the spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency of the resultant PPy-PVP NPs was systematically studied. By choosing PVP with a molecular weight of 360 kDa (concentration of 5 mg/mL) as the template and surface modifier during the synthesis, PPy-PVP NPs with optimal spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency were synthesized. Findings in this study are anticipated to provide an in-depth understanding of the important character of surface engineering in the rational design and biomedical applications of PPy NPs.