THE RETURN OF PANCREATIC RIBONUCLEASES
THE RETURN OF PANCREATIC RIBONUCLEASES
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DOI：
10.1016/0968-0004(89)90282-x
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发表时间：
1989-10-01
影响因子：
13.8
通讯作者：
ALLEMANN, RK
中科院分区：
文献类型：
--
作者：
BENNER, SA;ALLEMANN, RK
十年后，胰腺核糖核酸酶被发现与一系列细胞外蛋白同源，这些蛋白可能会影响肿瘤细胞的生长、神经发育和生物分化。这些发现的一个令人惊讶的结果是证实了细胞外“通讯分子RNA”是细胞生长和分化中重要的信使的假设。唯一的问题是：为什么没有更早地认识到这一点？牛胰腺核糖核酸酶(RNase)是20世纪60年代生化研究的核心酶。Anfinsen使用RNase作为他在蛋白质折叠方面的许多诺贝尔奖获奖工作的模型1。桑德斯选择RNase作为第一个被NMR2“3研究的酶。RNase是分子进化的早期范例4，它有超过50个同源序列已知。
A decade after losing favor as an'uninteresting'digestive enzyme, pancreatic ribonuclease has been found to be homologous to a series of extracellular proteins that may influence tumor cell growth, neurological development and biological differentiation. One surprising outcome of these discoveries has been the confirmation of the hypothesis that extracellular'communicator RNA'is a messenger important in cell growth and differentiation. The only question is: why wasn't this recognized earlier?Bovine pancreatic ribonuclease (RNase) was an enzyme central to biochemical research in the 1960s. Anfinsen used RNase as a model for muchof his Nobel prize-winning work on protein folding 1. Saunders chose RNase as the first enzyme to be studied by NMR 2" 3. With the sequences of over 50 homologues known, RNase was an early paradigm of molecular evolution 4.