Altering expectancy dampens neural response to aversive taste in primary taste cortex
Altering expectancy dampens neural response to aversive taste in primary taste cortex
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DOI：
10.1038/nn1645
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发表时间：
2006-03-01
影响因子：
25
通讯作者：
Davidson, RJ
中科院分区：
文献类型：
--
作者：
Nitschke, JB;Dixon, GE;Davidson, RJ
初级味觉皮层由腭和盖组成。先前的研究表明，初级味觉皮层的神经元只对来自味觉受体和舌体感觉受体的感觉输入做出反应。使用功能性磁共振成像，我们在这里表明，预期调节人类的这些神经反应。当受试者被引导相信一种高度厌恶的苦味会比实际上不那么令人厌恶时，他们报告说，与他们有关于味道的准确信息时相比，它不那么令人厌恶，而且，初级味觉皮层的激活也不那么强烈。此外，激活右丘脑和鳃盖可以追踪每种口味的厌恶程度的在线评级。这种由预期驱动的初级感觉皮层的调制可能会影响对外部事件的感知。
The primary taste cortex consists of the insula and operculum. Previous work has indicated that neurons in the primary taste cortex respond solely to sensory input from taste receptors and lingual somatosensory receptors. Using functional magnetic resonance imaging, we show here that expectancy modulates these neural responses in humans. When subjects were led to believe that a highly aversive bitter taste would be less distasteful than it actually was, they reported it to be less aversive than when they had accurate information about the taste and, moreover, the primary taste cortex was less strongly activated. In addition, the activation of the right insula and operculum tracked online ratings of the aversiveness for each taste. Such expectancy-driven modulation of primary sensory cortex may affect perceptions of external events.