Serum Klotho Levels Contribute to the Prevention of Disease Progression.
Serum Klotho Levels Contribute to the Prevention of Disease Progression.
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DOI：
10.2147/ijgm.s291437
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发表时间：
2021
影响因子：
2.3
通讯作者：
Yamauchi-Takihara K
中科院分区：
文献类型：
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作者：
Nakanishi K;Nishida M;Taneike M;Yamamoto R;Moriyama T;Yamauchi-Takihara K
从临床前状态评估疾病的进展对于预防各种疾病非常重要。在本研究中，我们评估了血清αKlotho（α KI）水平在几种临床前疾病进展中的作用。这项队列研究包括80名男性，他们在2005年4月至2008年3月期间接受了年度健康检查。从所有受试者获得物理和生化参数。本研究评估了基线血清可溶性αKl（sαKl）水平与疾病进展的相关性。空腹血糖（FPG）水平升高的受试者的基线血清sαKl水平显著低于FPG水平未升高的受试者。Logistic多因素分析显示，基线血清sαKl水平和FPG水平与高FPG水平进展显著相关。提示低sαKl水平与高血糖的进展有关。对患有多种疾病的受试者的血清sαKl水平的评价显示，临床前疾病进展较多的受试者倾向于显示较低的sαKl水平。血清sαKl水平降低可能与临床前疾病进展相关。
Assessing the progression of a disorder from its pre-clinical state is important in the prevention of various diseases. In the present study, we evaluated the role of serum levels of αKlotho (αKl) in the progression of several pre-clinical disorders. This cohort study included 80 males who underwent their annual health checkup during the entry period between April 2005 and March 2008. Physical and biochemical parameters were obtained from all subjects. The associations of baseline serum levels of soluble αKl (sαKl) with the progression of the disorders were assessed in the study. Baseline serum levels of sαKl were significantly lower in subjects developing a high fasting plasma glucose (FPG) level than in subjects not developing a high FPG level. Logistic multivariable analysis showed that baseline serum levels of sαKl and FPG levels significantly associated with a high FPG level progression. It is suggested that low sαKl levels are associated with the progression of hyperglycemia. Evaluation of serum levels of sαKl in subjects with multiple disorders revealed that those with more pre-clinical disorders progression tended to show lower sαKl levels. A decrease in serum levels of sαKl could be associated with the progression of pre-clinical disorders.