OSMOTIC THIRST AND VASOPRESSIN RELEASE IN HUMANS - A DOUBLE-BLIND CROSSOVER STUDY
OSMOTIC THIRST AND VASOPRESSIN RELEASE IN HUMANS - A DOUBLE-BLIND CROSSOVER STUDY
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DOI：
10.1152/ajpregu.1985.248.6.r645
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
MORTON, JJ
中科院分区：
文献类型：
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作者：
PHILLIPS, PA;ROLLS, BJ;MORTON, JJ
口渴是一种主观感觉。为了探讨渗透性口渴的性质、强度和特异性，在7名健康志愿者中研究了高渗（0.45 M）和等渗（0.15 M）盐水双盲输注对主观评级和口渴感、饮水量、血浆加压素和体液的影响。只有高渗盐水显着增加血浆钠浓度，血浆渗透压，血浆加压素浓度和视觉模拟等级的口渴感觉。两种输注都扩大了血容量，高渗盐水输注更大。两种溶液均未显著改变平均动脉血压和血浆血管紧张素水平。在输注后60分钟的饮水期内，高渗盐水组的饮水量始终显著高于等渗盐水组。受试者描述口渴的感觉主要是由于口干舌燥，喝了酒后很快就缓解了。视觉模拟评级变化证实了主观报告。在生理范围内的血浆钠浓度和渗透压变化，观察口渴和加压素分泌的影响。
Thirst is a subjective sensation. To investigate the nature, intensity and specificity of osmotic thirst, the effects of double-blind infusions of hypertonic (0.45 M) and isotonic (0.15 M) saline on subjective ratings and sensations of thirst, water intake, plasma vasopressin and body fluids were studied in 7 healthy volunteer young men. Only the hypertonic saline significantly increased plamsa Na concentration, plasma osmolality, plasma vasopressin concentration and visual analog ratings of thirst sensations. Both infusions expanded blood volume, which was greater with the hypertonic saline infusion. Neither solution significantly altered mean arterial blood pressure nor plasma angiotensin levels. Throughut a 60-min drinking period after the infusions, water intake was always significantly greater after the hypertonic saline than after the isotonic saline. The subjects described the thirst sensations as mainly due to a dry unpleasant tasting mouth, which was promptly relieved by drinking. Visual analog rating changes confirmed the subjective reports. The effects on thirst and vasopressin secretion were observed at plasma Na concentration and osmolality changes that are well within the physiological range.