Osmotic pressure of serum and cerebrospinal fluid in patients with suspected neurological conditions
Osmotic pressure of serum and cerebrospinal fluid in patients with suspected neurological conditions
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DOI：
10.4103/1673-5374.268906
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发表时间：
2020-05-01
影响因子：
6.1
通讯作者：
Ishii, Tadashi
中科院分区：
文献类型：
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作者：
Akaishi, Tetsuya;Takahashi, Toshiyuki;Ishii, Tadashi
脑实质中的间质液运动被认为有助于维持脑实质中的代谢以及维持神经元和胶质细胞的功能。脉动流体静压梯度可能是这种整体流动的驱动力之一。然而，渗透压相关的因素还没有研究到现在。在这项前瞻性观察性研究中，为了阐明血清和脑脊液（CSF）渗透压摩尔浓度（mOsm/kg）之间的关系，我们同时测量了179例疑似神经系统疾病受试者的血清和CSF渗透压摩尔浓度。血清渗透压摩尔浓度为283.6 +/- 6.5 mOsm/kg，CSF渗透压摩尔浓度为289.5 +/- 6.6 mOsm/kg。由于已知血清和CSF的比重分别为1.024-1.028和1.004-1.007，因此血清和CSF中的渗透压摩尔浓度（mOsm/L）的估计平均值涵盖完全相同的范围（即，290.5-291.5 mOsm/L）。CSF渗透压与血清渗透压之间有很强的相关性，但血清和CSF渗透压之间的差异与血清渗透压、血清电解质水平、蛋白水平或白蛋白商无关。总之，建议CSF渗透压等于血清渗透压。渗透压不是这种整体流动的驱动力之一。其他因素，如静水压力梯度，应用来解释在脑实质中的整体流动的机制。本研究于2015年7月29日获得东北大学附属医院机构审查委员会的批准（批准编号IRB No. 2015-1-257）。
Interstitial fluid movement in the brain parenchyma has been suggested to contribute to sustaining the metabolism in brain parenchyma and maintaining the function of neurons and glial cells. The pulsatile hydrostatic pressure gradient may be one of the driving forces of this bulk flow. However, osmotic pressure-related factors have not been studied until now. In this prospective observational study, to elucidate the relationship between osmolality (mOsm/kg) in the serum and that in the cerebrospinal fluid (CSF), we simultaneously measured the serum and CSF osmolality of 179 subjects with suspected neurological conditions. Serum osmolality was 283.6 +/- 6.5 mOsm/kg and CSF osmolality was 289.5 +/- 6.6 mOsm/kg. Because the specific gravity of serum and CSF is known to be 1.024-1.028 and 1.004-1.007, respectively, the estimated average of osmolarity (mOsm/L) in the serum and CSF covered exactly the same range (i.e., 290.5-291.5 mOsm/L). There was strong correlation between CSF osmolality and serum osmolality, but the difference in osmolality between serum and CSF was not correlated with serum osmolality, serum electrolyte levels, protein levels, or quotient of albumin. In conclusion, CSF osmolarity was suggested to be equal to serum osmolarity. Osmolarity is not one of the driving forces of this bulk flow. Other factors such as hydrostatic pressure gradient should be used to explain the mechanism of bulk flow in the brain parenchyma. This study was approved by the Institutional Review Board of the Tohoku University Hospital (approval No. IRB No. 2015-1-257) on July 29, 2015.