Diminished ovarian reserve in Behçet’s disease patients
Diminished ovarian reserve in Behçet’s disease patients
复制标题
白塞氏病患者的卵巢储备功能下降
DOI：
10.1007/s10067-014-2680-5
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发表时间：
2014
影响因子：
3.4
通讯作者：
C. Silva
中科院分区：
文献类型：
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作者：
A. Mont’Alverne;L. Yamakami;C. Gonçalves;E. Baracat;E. Bonfá;C. Silva
本研究旨在评估Behçet病(BD)患者的卵巢储备标志物。测定10例BD患者和22例健康对照的卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇、抑制素B、清晨总睾酮、催乳素、促甲状腺激素(TSH)和有腔卵泡计数，以评价卵巢储备功能。用两种不同的酶联免疫吸附试验(ELISA)试剂盒检测抗苗勒氏激素(AMH)。还分析了人口统计数据、月经异常、疾病参数和治疗方法。BD患者和对照组的当前年龄中位数相似(34(20-40)岁比31.3(20-42) ，p = 0.33)。在BD患者(r = +0.98；p <； 0.0001)和健康对照组(r = +0.93；p <； 0.0001)中，AMH基因II酶联免疫吸附试验与AMH/MISAnshLabs酶联免疫吸附试验呈正相关。与对照组相比，BD患者第二代的平均AMH(0.93 ± 0.8vs.2.5 9 ± 1.8 ng/m L，p = 0.0 1)和AMH/M IS AnshLabs EL ISA(1.0 7 ± 0.86对2.5 1 ± 1.8 ng/m L，p = 0.0 2)显著降低。与使用任何一种试剂盒的对照组相比，BD患者的AMH(<；1.0 ng/mL)有下降的趋势(50%vs.19%，p = 0.09)。BD组平均促卵泡刺激素水平显著高于对照组(9.1FSH± 3.6vs.6.5 ± 2.7p = 0.04)。其他卵巢参数两组间差异无统计学意义(p >； )。目前的疾病活动仅在低AMH水平的BD患者中观察到；然而，没有统计学意义(40vs.0%，p = 0.44)。只有一名低AMH和高FSH水平的患者报告使用环磷酰胺。这项研究首次表明BD患者可能降低了卵巢储备。疾病活动的贡献仍有待确定。
This study aims to assess ovarian reserve markers in Behçet's disease (BD) patients. Ten BD and 22 healthy controls were evaluated for ovarian reserve by examining the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, inhibin B, total morning testosterone, prolactin, thyroid-stimulating hormone (TSH), and antral follicle count. Anti-Müllerian hormone (AMH) was measured using two different enzyme-linked immunosorbent assay (ELISA) kits. Demographic data, menstrual abnormalities, disease parameters, and treatments were also analyzed. The median current age was similar in BD patients and controls (34 (20–40) vs. 31.3 (20–42) years, p = 0.33). A positive correlation was observed between the AMH Gen II ELISA and AMH/MISAnshLabs ELISA assays in the BD patients (r = +0.98; p < 0.0001) and healthy controls (r = +0.93; p < 0.0001). The mean AMH by Gen II (0.93 ± 0.8 vs. 2.59 ± 1.8 ng/mL, p = 0.01) and AMH/MIS AnshLabs ELISA (1.07 ± 0.86 vs. 2.51 ± 1.8 ng/mL, p = 0.02) were significantly reduced in the BD patients versus controls. A trend of decreased AMH (<1.0 ng/mL) was observed in BD patients compared to that in the controls (50 vs. 19 %, p = 0.09) using either kits. The mean FSH was significantly higher in the BD patients compared to that in the controls (9.1 ± 3.6 vs. 6.5 ± 2.7, p = 0.04). No differences were found for the other ovarian parameters in both groups (p > 0.05). Current disease activity was only observed in BD patients with a low AMH level; however, there was no statistical significance (40 vs. 0 %, p = 0.44). Cyclophosphamide use was reported in only one patient with a low AMH and high FSH level. The present study was the first to suggest that BD patients may have diminished ovarian reserve. The contribution of disease activity remains to be determined.