Competitive integration of visual and preparatory signals in the superior colliculus during saccadic programming
Competitive integration of visual and preparatory signals in the superior colliculus during saccadic programming
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DOI：
10.1523/jneurosci.4212-06.2007
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发表时间：
2007-05-09
影响因子：
5.3
通讯作者：
Munoz, Doug P.
中科院分区：
文献类型：
--
作者：
Dorris, Michael C.;Olivier, Etienne;Munoz, Doug P.
有效的行为要求内部指定的运动计划与传入的感官信息相结合。运动准备和视觉信号汇聚在上级丘（SC）的中间层和深层，影响扫视规划和执行，然而，这些有时相互冲突的信号相结合的机制仍然不清楚。我们研究了这个问题，提出了视觉干扰，猴子准备扫视即将到来的目标，其时间和位置是完全可预测的。当视觉干扰物的空间位置与扫视目标更接近时，猴子会犯更多的干扰物导向错误。伴随前靶活动的SC视觉神经元，其反应领域集中在扫视目标，同样增加了附近的干扰和抑制的介绍，提出了遥远的干扰。最后，阈下微刺激的SC转移模式的分心物导向的错误远离眼跳的目标，对指定的网站的刺激。总之，我们的研究结果表明，扫视产生的可能性是由内部运动准备信号和外部感觉信号的空间寄存器的地形组织的SC地图的影响。
Efficient behavior requires that internally specified motor plans be integrated with incoming sensory information. Motor preparation and visual signals converge in the intermediate and deep layers of the superior colliculus (SC) to influence saccade planning and execution; however, the mechanism by which these sometimes conflicting signals are combined remains unclear. We studied this issue by presenting visual distractors as monkeys prepared saccades toward an upcoming target whose timing and location were fully predictable. Monkeys made more distractor-directed errors when the spatial location of visual distractors more closely coincided with the saccadic goal. Concomitant pretarget activity of SC visuomotor neurons, whose response fields were centered on the saccadic goal, was similarly increased by the presentation of nearby distractors and inhibited by the presentation of distant distractors. Finally, subthreshold microstimulation of the SC shifted the pattern of distractor-directed errors away from the saccadic goal toward that specified by the site of stimulation. Together, our results suggest that the likelihood of saccade generation is influenced by the spatial register of internal motor preparation signals and external sensory signals across the topographically organized SC map.