Common Core Bacterial Biomarkers of Bladder Cancer Based on Multiple Datasets
Common Core Bacterial Biomarkers of Bladder Cancer Based on Multiple Datasets
复制标题
基于多个数据集的膀胱癌共同核心细菌生物标志物
DOI：
10.1155/2019/4824909
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发表时间：
2019-06-19
影响因子：
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通讯作者：
Ma, Yingfei
中科院分区：
文献类型：
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作者：
Mai, Guoqin;Chen, Limei;Ma, Yingfei
最近的研究表明，微生物可能与膀胱癌的发生和发展有关。本研究的目的是确定与膀胱癌相关的常见核心细菌。我们通过16S rRNA基因测序对膀胱癌患者的尿液微生物谱进行了表征，并且在我们实验室收集的24个膀胱癌样本的结果显示了31个属水平的常见核心细菌。此外，根据之前的两个数据集，膀胱癌样本中四种常见核心细菌的丰度显著高于LEfSe分析的非患病人群样本。特别是，膀胱癌样品中不动杆菌的丰度要高得多。据报道，不动杆菌不仅参与生物膜的形成，还参与上皮细胞的粘附和侵袭、粘膜屏障中磷脂降解引起的细菌传播以及宿主免疫反应的逃避。因此，不动杆菌可能与膀胱癌有关，是膀胱癌潜在的微生物标志物。然而，由于参与者数量有限，需要进一步研究以更好地了解微生物在膀胱癌中的作用，为诊断，预后和治疗提供新的生物标志物。
Recent studies have shown that microorganisms may be associated with the onset and development of bladder cancer. The purpose of this study is to identify the common core bacteria associated with bladder cancer. We characterized the urinary microbial profile of the individuals with bladder cancer by 16S rRNA gene sequencing, and the results of 24 bladder cancer samples collected in our laboratory reveal 31 common core bacteria at genera level. In addition, the abundance of four common core bacteria is significantly higher in bladder cancer samples than in samples from nondiseased people analyzed by LEfSe, based on two previous datasets. In particular, the abundance of Acinetobacter is much higher in bladder cancer samples. It has been reported that Acinetobacter is involved not only in biofilm formation but also in the adhesion and invasion of epithelial cells, the spread of bacteria caused by the degradation of phospholipids in the mucosal barrier, and the escape of the host immune response. Thus, Acinetobacter may be related to bladder cancer and is a potential microbial marker of bladder cancer. However, due to the limited number of participants, further studies are needed to better understand the role of microorganisms in bladder cancer to provide novel biomarkers for diagnosis, prognosis, and therapy.