Binge drinking during adolescence and young adulthood is associated with deficits in verbal episodic memory
Binge drinking during adolescence and young adulthood is associated with deficits in verbal episodic memory
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DOI：
10.1371/journal.pone.0171393
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发表时间：
2017-02-02
期刊：
影响因子：
3.7
通讯作者：
Corral, Montse
中科院分区：
文献类型：
--
作者：
Carbia, Carina;Cadaveira, Fernando;Corral, Montse
酗酒（BD）是一种有害的酒精消费模式，在青春期很常见。患有酒精使用障碍的年轻人表现出海马体改变和情景记忆缺陷。然而，目前尚不清楚这些困难在社区双相障碍青少年中如何发展。我们的目的是分析双相障碍的发展轨迹和从青春期到成年早期的言语情景记忆之间的关系。研究人员对155名没有其他危险因素的大学一年级男女学生进行了为期六年的跟踪调查。根据第三个审计项目，参与者被分为稳定的非bd、稳定的bd和前bd。基线时，参与者包括36名男性/40名女性非bd患者（18.58岁），40名男性/39名女性bd患者（18.87岁），第三次随访时，参与者包括8名cf/ 89名稳定的非bd患者（25.49岁），2名男性/2名女性稳定的bd患者（25.40岁）和8名男性/12名女性前bd患者（24.97岁）。情景记忆用逻辑记忆子测试（WMS-III）和雷伊听觉言语学习测试（RAVLT）进行了四次评估。采用广义线性混合模型。结果表明，在逻辑记忆子测试中，相对于非bd者，稳定bd者在即时和延迟回忆方面存在困难。随着时间的推移，这些困难保持稳定。短期戒烟者在逻辑记忆子测试中继续表现出即时和延迟回忆的困难，而长期戒烟者则没有。效果不受酒精发作年龄、大麻使用频率、烟草使用或精神病理困扰的影响。总之，青春期和青年期的双相障碍与情景记忆缺陷有关。放弃BD模式可能导致部分恢复。这些发现与青少年海马体对酒精的神经毒性作用的脆弱性相一致。
Binge drinking (BD), a harmful pattern of alcohol consumption, is common during adolescence. Young adults with alcohol use disorders exhibit hippocampal alterations and episodic memory deficits. However, it is not known how these difficulties progress in community BD adolescents. Our objective was to analyze the relationship between BD trajectory and verbal episodic memory during the developmental period spanning from adolescence and to early adulthood. An initial sample of 155 male and female first-year university students with no other risk factors were followed over six years. Participants were classified as stable nonBDs, stable BDs and ex-BDs according to the third AUDIT item. At baseline, participants comprised 36 male/40 female non-BDs (18.58 years), 40 male/39 female BDs (18.87 years), and at the third follow-up, they comprised 8 cf/8 9 stable non-BDs (25.49 years), 2 male/2 female stable BDs (25.40) and 8 male/12 female ex-BDs (24.97 years). Episodic memory was assessed four times with the Logical Memory subtest (WMS-III) and the Rey Auditory Verbal Learning Test (RAVLT). Generalized linear mixed models were applied. The results showed that, relative to non-BDs, stable BDs presented difficulties in immediate and delayed recall in the Logical Memory subtest. These difficulties remained stable over time. The short-term ex-BDs continued to display difficulties in immediate and delayed recall in the Logical Memory subtest, but long-term ex-BDs did not. The effects were not influenced by age of alcohol onset, frequency of cannabis use, tobacco use or psychopathological distress. In conclusion, BD during adolescence and young adulthood is associated with episodic memory deficits. Abandoning the BD pattern may lead to partial recovery. These findings are consistent with the vulnerability of the adolescent hippocampus to the neurotoxic effects of alcohol.