Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment
Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment
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DOI：
10.1118/1.1521720
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发表时间：
2002-12-01
期刊：
影响因子：
3.8
通讯作者：
Wang, LHV
中科院分区：
文献类型：
--
作者：
Wang, XD;Xu, Y;Wang, LHV
一种改进的反投影方法推导出一个精确的重建解决方案被应用到我们的光声层析在生物组织中的光吸收。采用来自Ti：蓝宝石激光器的脉冲（在789.2nm处的4.7ns FWHM）以在样品中产生光声源的分布。在垂直于激光照射轴的成像横截面周围的不同位置处，由宽带非聚焦超声换能器检测源。从鸡胸组织制成的模型的重建图像与样品的结构一致。实验证明，当采用10 MHz换能器（-60 dB处的140%带宽）时，成像横截面中的分辨率优于60 μ m，这几乎是由最高频率的可检测光声波衍射限制的。(C)2002年美国医学物理学家协会。
A modified back-projection approach deduced from an exact reconstruction solution was applied to our photoacoustic tomography of the optical absorption in biological tissues. Pulses from a Ti:sapphire laser (4.7 ns FWHM at 789.2 nm) were employed to generate a distribution of photoacoustic sources in a sample. The sources were detected by a wide-band nonfocused ultrasonic transducer at different positions around the imaging cross section perpendicular to the axis of the laser irradiation. Reconstructed images of phantoms made from chicken breast tissue agreed well with the structures of the samples. The resolution in the imaging cross section was experimentally demonstrated to be better than 60 mum when a 10 MHz transducer (140% bandwidth at -60 dB) was employed, which was nearly diffraction limited by the detectable photoacoustic waves of the highest frequency. (C) 2002 American Association of Physicists in Medicine.