Retrosplenial and Hippocampal Synchrony during Retrieval of Old Memories in Macaques.
Retrosplenial and Hippocampal Synchrony during Retrieval of Old Memories in Macaques.
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DOI：
10.1523/jneurosci.0001-22.2022
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发表时间：
2022-10-19
影响因子：
5.3
通讯作者：
Hoffman, Kari L.
中科院分区：
文献类型：
--
作者：
Hussin, Ahmed T.;Abbaspoor, Saman;Hoffman, Kari L.
关键词：
对遥远过去事件的记忆依赖于多个大脑区域，但人们对产生这种能力的潜在神经动力学知之甚少。我们记录了两只雌性恒河猴在一岁和新获得的物体-场景关联中视觉选择目标时海马和脾后皮层的神经活动。尽管海马活动随记忆年龄的增长而保持不变，但在回忆旧事件时，脾后皮层对记忆引导的眼球运动有更大的α振荡（10-15 Hz）和更大的相锁定反应。在前扣带皮层观察到类似的旧记忆增强，但在β 2/ γ波段（28-35 Hz）。相比之下，远程检索与海马和每个新皮质区域之间的伽马带同步减少有关。随着记忆年龄的增长，脾后α振荡的增加和海马皮层同步的减少可能表明坦率记忆分配的转变，或者，灵长类大脑中分布式记忆表征的选择发生了变化。记忆依赖于多个大脑区域，它们的参与被认为随着时间的推移而改变。在这里，我们记录了非人类灵长类动物在寻找场景中嵌入的物体时海马和脾后皮层的神经元群活动。这些备忘录要么是新提交的，要么是一年前的。记忆旧的材料会在脾后皮层产生更强的振荡，并导致更强的神经活动锁定以搜索运动。记忆新材料显示海马和脾后皮层之间更强的振荡同步。这些结果表明，随着年龄的增长，记忆可能更多地依赖于新皮层的振荡来检索和搜索指导，而较少依赖于与海马体的远程耦合。
Memory for events from the distant past relies on multiple brain regions, but little is known about the underlying neural dynamics that give rise to such abilities. We recorded neural activity in the hippocampus and retrosplenial cortex of two female rhesus macaques as they visually selected targets in year-old and newly acquired object-scene associations. Whereas hippocampal activity was unchanging with memory age, the retrosplenial cortex responded with greater magnitude alpha oscillations (10–15 Hz) and greater phase locking to memory-guided eye movements during retrieval of old events. A similar old-memory enhancement was observed in the anterior cingulate cortex but in a beta2/gamma band (28–35 Hz). In contrast, remote retrieval was associated with decreased gamma-band synchrony between the hippocampus and each neocortical area. The increasing retrosplenial alpha oscillation and decreasing hippocampocortical synchrony with memory age may signify a shift in frank memory allocation or, alternatively, changes in selection among distributed memory representations in the primate brain. SIGNIFICANCE STATEMENT Memory depends on multiple brain regions, whose involvement is thought to change with time. Here, we recorded neuronal population activity from the hippocampus and retrosplenial cortex as nonhuman primates searched for objects embedded in scenes. These memoranda were either newly presented or a year old. Remembering old material drove stronger oscillations in the retrosplenial cortex and led to a greater locking of neural activity to search movements. Remembering new material revealed stronger oscillatory synchrony between the hippocampus and retrosplenial cortex. These results suggest that with age, memories may come to rely more exclusively on neocortical oscillations for retrieval and search guidance and less on long-range coupling with the hippocampus.