Glyceryl trinitrate triggers premonitory symptoms in migraineurs
Glyceryl trinitrate triggers premonitory symptoms in migraineurs
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DOI：
10.1016/j.pain.2004.05.007
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发表时间：
2004-08-01
期刊：
影响因子：
7.4
通讯作者：
Goadsby, PJ
中科院分区：
文献类型：
--
作者：
Afridi, SK;Kaube, H;Goadsby, PJ
研究偏头痛的发作是相当大的阻碍，其根本的情节性质。开发可靠地触发偏头痛的方法对于通过促进其研究来促进对该疾病的理解是重要的。基于哥本哈根小组的工作，我们对44名偏头痛患者、23名无先兆偏头痛患者、21名有先兆偏头痛患者和12名健康对照者静脉输注0.5 μ g/kg/min三硝酸甘油（GTN）。我们试图从发作的临床特征和触发的可重复性方面来研究GTN诱发的偏头痛，并包括一个非偏头痛对照组，目的是比较任何效应，以排除排序效应。在44名服用GTN的患者中，33名偏头痛发作符合国际头痛协会标准。32例为无先兆偏头痛，1例为有先兆偏头痛。12例患者描述了典型的先兆症状，这是以前没有记录的GTN引起的偏头痛。除了一个实验对象外，所有实验对象都再次发作。在一个案例中，视觉光环也被两次触发。我们的研究表明，GTN诱导的触发在我们的患者中很常见，并且具有显著的可重复性。这些数据将有助于在需要广泛计划的研究中使用GTN模型，例如脑成像，或预防问题。我们还报告了第一个病人与一个可重复的GTN触发偏头痛的先兆。(C)2004年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
Studying attacks of migraine is considerably hampered by its fundamentally episodic nature. Developing approaches to triggering migraine reliably is important for advancing understanding of the disorder by facilitating its study. Based on the work of the Copenhagen Group we administered an intravenous infusion of 0.5 mug/kg/min glyceryl trinitrate (GTN) to 44 migraineurs, 23 migraine without aura, 21 migraine with aura, and to 12 healthy controls. We sought to characterise the GTN-induced migraine in terms of the clinical features of the attacks and reproducibility of triggering, and included a non-migraine control group for the purpose of comparing any effects to exclude an ordering effect. Of the 44 patients administered GTN, 33 had a migraine attack fulfilling International Headache Society criteria. Thirty-two attacks were of migraine without aura and one of migraine with aura. Twelve patients described typical premonitory symptoms, which have not been previously documented with GTN-induced migraine. A repeat attack was triggered in all subjects but one. In one case a visual aura was also triggered both times. Our study shows that GTN-induced triggering is common in our patients, and remarkably reproducible. The data will facilitate the use of the GTN model in studies requiring extensive planning, such as brain imaging, or where preventive questions are at issue. We also report the first patient with a reproducible GTN-triggered migraine with aura. (C) 2004 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.