Dynamics of the Antibody Response to Plasmodium falciparum Infection in African Children
Dynamics of the Antibody Response to Plasmodium falciparum Infection in African Children
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DOI：
10.1093/infdis/jiu219
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发表时间：
2014-10-01
影响因子：
6.4
通讯作者：
Ghani, Azra C.
中科院分区：
文献类型：
--
作者：
White, Michael T.;Griffin, Jamie T.;Ghani, Azra C.
背景资料。人们普遍认为，对疟疾的获得性免疫反应是短暂的，以前免疫的人在离开疟疾流行地区时会失去免疫力。然而，经常观察到持续个体一生的恶性疟原虫特异性抗体应答。我们拟合了非洲儿童纵向队列研究中恶性疟原虫抗体滴度动态的数学模型，以估计循环免疫球蛋白G抗体和免疫球蛋白抗体分泌细胞的半衰期。对年轻的加纳人和年长的冈比亚人的抗体反应进行比较表明，年幼的儿童较少能够产生维持循环抗体所需的长期存活的ASCs，这种抗体可能提供保护，防止再次感染。非洲儿童的抗体反应可以用模型15来描述，模型15既包括短寿命(半衰期，2-10天)和长寿命(半衰期，3-9年)ASCs，前者负责提高感染后的抗体效价，后者负责维持持续的体液反应。在接触疟疾后抗体迅速衰退和维持持续的抗体反应可以用短期和长期的ASCs种群来解释。
Background. Acquired immune responses to malaria have widely been perceived to be short-lived, with previously immune individuals losing immunity when they move from malaria-endemic areas. However long-lived Plasmodium falciparum-specific antibody responses lasting for an individual's lifetime are frequently observed.Methods. We fit mathematical models of the dynamics of antibody titers to P. falciparum antigens from longitudinal cohort studies of African children to estimate the half-lives of circulating immunoglobulin G (IgG) antibodies and IgG antibody-secreting cells (ASCs).Results. Comparison of antibody responses in the younger Ghanaian cohort and the older Gambian cohort suggests that young children are less able to generate the long-lived ASCs necessary to maintain the circulating antibodies that may provide protection against reinfection. Antibody responses in African children can be described by a model 15 including both short-lived ASCs (half-life range, 2-10 days), which are responsible for boosting antibody titers following infection, and long-lived ASCs (half-life range, 3-9 years), which are responsible for maintaining sustained humoral responses.Conclusions. The rapid decay of antibodies following exposure to malaria and the maintenance of sustained antibody responses can be explained in terms of populations of short-lived and long-lived ASCs.