The association between breastfeeding, the stress response, inflammation, and postpartum depression during the postpartum period: Prospective cohort study.
The association between breastfeeding, the stress response, inflammation, and postpartum depression during the postpartum period: Prospective cohort study.
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DOI：
10.1016/j.ijnurstu.2015.05.017
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发表时间：
2015-10
影响因子：
8.1
通讯作者：
Corwin EJ
中科院分区：
文献类型：
--
作者：
Ahn S;Corwin EJ
研究表明，纯母乳喂养可能会对产后抑郁症起到压力保护作用，然而，关于这种保护可能发生的潜在机制，或者这种保护关系是否适用于母乳和奶粉混合喂养的女性，人们知之甚少。研究产后6个月以母乳喂养或奶瓶喂养为主的妇女的应激反应、炎症和抑郁症状的模式。产后6个月的大型纵向研究的一部分，调查产后抑郁症的心理神经免疫学(PNI)。产前诊所和社区。119名符合纳入/排除标准的产后妇女，从产前到产后6个月进行了跟踪调查。在妊娠晚期(32-36周)、产后7天和14天、1个月、2个月、3个月和6个月的7次家访中收集了数据。妇女完成了应激和抑郁调查，并提供了前(IL-1β、IL-6、IL-8、肿瘤坏死因子-α、干扰素-γ)和抗炎(IL-10)细胞因子的血液，并采集了唾液中的皮质醇。产后6个月以母乳喂养为主的自述比例从产后7天的91.9%到产后6个月的70.6%。进食方式和抑郁症状之间没有关联。然而，两组之间存在生物学差异，在控制了混杂变量后，主要母乳喂养的女性在6个月的上午8点和8：30的唾液皮质醇水平比主要用奶瓶喂养的婴儿的唾液皮质醇水平高，而6个月的IL-6水平低。母乳喂养与产后抑郁无关，然而，在产后6个月，压力和炎症标记物的差异明显。
Research suggests that exclusive breastfeeding may have a stress-protective role in postpartum depression, however, less is known about the underlying mechanisms by which this protection may occur or whether the protective relationship holds for women who mix breast and bottle feeding. To examine patterns of the stress response, inflammation, and depressive symptoms among women predominantly breastfeeding or bottle feeding their infants at 6 months postpartum. A part of a larger longitudinal study across 6 months postpartum investigating the psychoneuroimmunology (PNI) of postpartum depression. Prenatal clinics and community. One hundred nineteen postpartum women who met inclusion/exclusion criteria and followed up from the prenatal period to postpartum 6 months. Data were collected during seven home visits occurring during the 3rd trimester (weeks 32–36) and on postpartum days 7 and 14, months 1, 2, 3, and 6. Women completed stress and depression surveys and provided blood for pro- (IL-1β, IL-6, IL-8, TNF-a, IFN-γ) and anti-inflammatory (IL-10) cytokines, and collected saliva for diurnal cortisol. Self-report of predominant breastfeeding during 6 months postpartum ranged from 91.9% at day 7 to 70.6% at month 6 postpartum. There were no associations between the pattern of feeding and depressive symptoms. Biological differences, however, existed between the groups, with levels of salivary cortisol at 8 AM and 8:30 AM at month 6 higher and levels of IL-6 at month 6 lower in women who primarily breastfed compared to those who primarily bottle fed their infants after controlling for confounding variables. Breastfeeding was not related to postpartum depression however differences in stress and inflammatory markers are apparent at month 6 postpartum.