Coffee and cancer risk: a summary overview
Coffee and cancer risk: a summary overview
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DOI：
10.1097/cej.0000000000000341
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发表时间：
2017-09-01
影响因子：
2.4
通讯作者：
La Vecchia, Carlo
中科院分区：
文献类型：
--
作者：
Alicandro, Gianfranco;Tavani, Alessandra;La Vecchia, Carlo
我们回顾了关于喝咖啡和所有癌症风险的现有证据，并选择了更新到2016年5月的癌症。咖啡消费量与总体癌症风险并不相关。一项荟萃分析报告说，对于所有癌症来说，每天喝一杯咖啡增加1.00[95%可信区间(CI)：0.99-1.01]的汇集相对风险(RR)。喝咖啡与降低患肝癌的风险有关。一项队列研究的荟萃分析发现，对于肝癌，每天增加1杯的RR为0.85(95%CI：0.81-0.90)，并对肝酶和肝硬变有良好的效果。另一项荟萃分析显示，子宫内膜癌的风险与之相反，每天每增加1杯，RR为0.92(95%CI：0.88-0.96)。一些研究发现，口腔/咽癌和晚期前列腺癌的风险可能会降低。尽管数据喜忧参半，但总体而言，在病例对照研究中，在队列研究中缺乏一致关系的情况下，饮用咖啡似乎对结直肠癌有一些有利的影响。对于膀胱癌，结果并不一致；然而，任何可能的直接联系都与剂量和持续时间无关，可能取决于吸烟的残余混杂效应。一些研究表明，母亲在怀孕期间喝咖啡会增加儿童白血病的风险，但数据有限且不一致。尽管研究结果喜忧参半，但总体证据表明，摄入咖啡与胃癌、胰腺癌、肺癌、乳腺癌、卵巢癌和前列腺癌没有关联。数据有限，其他肿瘤的RR接近统一，包括食道、小肠、胆囊管、皮肤、肾脏、脑、甲状腺的肿瘤，以及软组织肉瘤和淋巴造血癌。版权所有(C)2017 Wolters KluwerHealth，Inc.保留所有权利。
We reviewed available evidence on coffee drinking and the risk of all cancers and selected cancers updated to May 2016. Coffee consumption is not associated with overall cancer risk. A meta-analysis reported a pooled relative risk (RR) for an increment of 1 cup of coffee/day of 1.00 [95% confidence interval (CI): 0.99-1.01] for all cancers. Coffee drinking is associated with a reduced risk of liver cancer. A meta-analysis of cohort studies found an RR for an increment of consumption of 1 cup/day of 0.85 (95% CI: 0.81-0.90) for liver cancer and a favorable effect on liver enzymes and cirrhosis. Another meta-analysis showed an inverse relation for endometrial cancer risk, with an RR of 0.92 (95% CI: 0.88-0.96) for an increment of 1 cup/day. A possible decreased risk was found in some studies for oral/pharyngeal cancer and for advanced prostate cancer. Although data are mixed, overall, there seems to be some favorable effect of coffee drinking on colorectal cancer in case-control studies, in the absence of a consistent relation in cohort studies. For bladder cancer, the results are not consistent; however, any possible direct association is not dose and duration related, and might depend on a residual confounding effect of smoking. A few studies suggest an increased risk of childhood leukemia after maternal coffee drinking during pregnancy, but data are limited and inconsistent. Although the results of studies are mixed, the overall evidence suggests no association of coffee intake with cancers of the stomach, pancreas, lung, breast, ovary, and prostate overall. Data are limited, with RR close to unity for other neoplasms, including those of the esophagus, small intestine, gallbladder and biliary tract, skin, kidney, brain, thyroid, as well as for soft tissue sarcoma and lymphohematopoietic cancer. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.