BLOCKADE OF ETHANOL INDUCED CONDITIONED TASTE-AVERSION BY 3-AMINO-1,2,4-TRIAZOLE - EVIDENCE FOR CATALASE MEDIATED SYNTHESIS OF ACETALDEHYDE IN RAT-BRAIN
BLOCKADE OF ETHANOL INDUCED CONDITIONED TASTE-AVERSION BY 3-AMINO-1,2,4-TRIAZOLE - EVIDENCE FOR CATALASE MEDIATED SYNTHESIS OF ACETALDEHYDE IN RAT-BRAIN
复制标题
DOI：
10.1016/0024-3205(85)90579-x
复制
发表时间：
1985-01-01
期刊：
影响因子：
6.1
通讯作者：
AMIT, Z
中科院分区：
文献类型：
--
作者：
ARAGON, CMG;SPIVAK, K;AMIT, Z
这项研究旨在提供大脑中乙醇通过过氧化氢酶的过氧化活性氧化的证据，同时提供中枢乙醛（ACH）在乙醇诱导的条件性味觉厌恶（CTA）介导中的作用的证据。乙醇能够引起条件性味觉厌恶。用过氧化氢酶抑制剂 3-氨基-1,2,4-三唑 (AT) 进行预处理，显示乙醇诱导的 CTA 减弱。接受乙醇注射的动物显示出对与药物给药配对的新溶液的 CTA，而用 AT 预处理的乙醇注射动物则没有显示出对乙醇给药的 CTA。 AT 的这种作用似乎是乙醇的作用所特有的，因为 CTA 对吗啡和氯化锂的作用不受 AT 预处理的影响。无论预处理如何，所有动物的外周乙醇水平都是相同的，这表明 AT 对外周乙醇水平没有影响。这些数据进一步支持了乙醛直接在大脑中产生并且它可能是介导乙醇的一些精神药理学特性的物质的观点。
This investigation seeks to present evidence for the oxidation of ethanol in the brain via the peroxidatic activity of catalase and simultaneously provide evidence for the role of central acetaldehyde (ACH) in the mediation of an ethanol-induced conditioned taste aversion (CTA). Ethanol is capable of inducing a conditioned taste aversion. Pretreatment with the catalase inhibitor, 3-amino-1, 2, 4-triazole (AT), shows an attenuation of this ethanol-induced CTA. Animals receiving ethanol injections showed a CTA to a novel solution paired with a drug administration, while ethanol injected animals pretreated with AT did not show a CTA to ethanol administration. This effect of AT appears to be specific to the effects of ethanol as CTA''s to morphine and lithium chloride were not affected by AT pretreatment. Peripheral levels of ethanol were the same in all animals regardless of pretreatment indicating that AT had no effect on peripheral levels of ethanol. These data increase support for the notion that acetaldehyde is produced directly in the brain and that it may be the agent mediating some of the psychopharmacological properties of ethanol.