Preterm Milk Oligosaccharides During the First Month of Lactation
Preterm Milk Oligosaccharides During the First Month of Lactation
复制标题
DOI：
10.1542/peds.2011-1206
复制
发表时间：
2011-12-01
期刊：
影响因子：
8
通讯作者：
Coppa, Giovanni V.
中科院分区：
文献类型：
--
作者：
Gabrielli, Orazio;Zampini, Lucia;Coppa, Giovanni V.
目的：低聚糖是母乳的主要成分之一，对新生儿具有重要的生物学功能。在质和量上，它们在乳汁中的存在与母亲Se和/或Le基因的表达密切相关，在此基础上描述了4种不同的乳汁群。本研究的目的是提供4组早产儿乳汁中低聚糖组成的新数据。方法：采用高ph阴离子交换色谱法对63例哺乳期母亲的252份乳汁样品中23种低聚糖和乳糖的含量进行定量分析，并鉴定出4种乳汁组。结果：各组间低聚糖含量存在显著差异，且与是否存在特异性焦酰基低聚糖密切相关。浓度以1组最高（>为20 g/L）， 4组最低（与10 g/L相近），2、3组为中间值。各组之间乳糖浓度没有统计学上的显著差异。结论：我们的数据证实，与足月乳相比，早产儿乳中的乳糖浓度较低，并且首次提供了早产儿乳中低聚糖的详细表征，显示了四组低聚糖含量的重要差异。这些差异可能会对几种生物功能产生影响，这些功能对早产儿特别重要，目前被认为是由牛奶低聚糖引起的。儿科2011;128: e1520-e1531
OBJECTIVE: Oligosaccharides represent one of the main components of human milk, and they have been assigned important biological functions for newborns. Qualitatively and quantitatively, their presence in milk is strictly related to the expression of the mother's Se and/or Le genes, on the basis of which 4 different milk groups have been described. The aim of the study was to provide new data on the oligosaccharide composition of preterm milk in relation to the 4 groups.METHODS: High-pH anion-exchange chromatography was used to quantify levels of 23 oligosaccharides and lactose in 252 milk samples collected from 63 mothers during the first month of lactation and to identify the 4 milk groups.RESULTS: Substantial differences in oligosaccharide contents were found within the groups and were strictly related to the presence or absence of specific fucosyl-oligosaccharides. The highest concentration was found in group 1 (> 20 g/L), the lowest level was found in group 4 (similar to 10 g/L), and intermediate values were observed in groups 2 and 3. No statistically significant differences in lactose concentrations were observed among the groups.CONCLUSIONS: Our data confirm lower lactose concentrations in preterm milk, compared with term milk, and they provide the first detailed characterization of oligosaccharides in preterm milk, demonstrating important differences in oligosaccharide contents in the 4 groups. These differences might exert an influence on several biological functions that are particularly important for preterm infants and currently are attributed to milk oligosaccharides. Pediatrics 2011;128:e1520-e1531