Tea tree oil reduces histamine-induced oedema in murine ears
Tea tree oil reduces histamine-induced oedema in murine ears
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DOI：
10.1007/pl00000305
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发表时间：
2002-06-01
影响因子：
6.7
通讯作者：
Hart, PH
中科院分区：
文献类型：
--
作者：
Brand, C;Townley, SL;Hart, PH
目的：为了研究局部应用茶树油（TTO）对组胺诱导的水肿在小鼠的耳朵的影响。方法和结果：对于BALB/c小鼠，10穆尔未稀释的TTO后立即应用，但不是30分钟前皮内注射600 μ g组胺在10穆尔，显着抑制水肿的发展。组胺注射后应用TTO也抑制组胺诱导的水肿C57/BL 6小鼠。在皮内注射化合物48/80（200 μ g在10穆尔盐水中）后立即施用TTO也显著降低耳肿胀。TTO抑制组胺诱导的水肿在辣椒素治疗（神经肽耗尽）和对照小鼠相同的程度，这表明TTO不抑制组胺诱导的水肿通过调节外周感觉神经元的活性。松油烯-4-醇，TTO的主要水溶性成分，相当于TTO在抑制组胺诱导的耳肿胀的效力。结论：TTO，特别是松油烯-4-醇的局部应用，可能是有效的组胺诱导的水肿往往与I型过敏性立即超敏反应。
Objective: To examine the effect of topically applied tea tree oil (TTO) on histamine-induced oedema in the ears of mice.Methods and results: For BALB/c mice, 10 mul undiluted TTO applied immediately after, but not 30 min before intradermal injection of 600 jig histamine in 10 mul, significantly suppressed oedema development. TTO applied after histamine injection also suppressed histamine-induced oedema in C57/BL6 mice. TTO applied immediately after intradermal injection of compound 48/80 (200 mug in 10 mul saline) also significantly reduced ear swelling. TTO suppressed histamine-induced oedema to the same extent in capsaicin-treated (neuropeptide-depleted) and control mice which suggests that TTO does not inhibit histamine-induced oedema by regulating the activity of peripheral sensory neurons. Terpinen-4-ol, the major water-soluble component of TTO, was equivalent in potency to TTO in the suppression of histamine-induced ear swelling.Conclusion: Topical application of TTO, and in particular terpinen-4-ol, may be effective in controlling histamine-induced oedema often associated with Type I allergic immediate hypersensitivities.