CHILDHOOD TYPE OF DERMATOMYOSITIS
CHILDHOOD TYPE OF DERMATOMYOSITIS
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DOI：
10.1212/wnl.26.10.952
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发表时间：
1976-01-01
期刊：
影响因子：
9.9
通讯作者：
WATTERS, G
中科院分区：
文献类型：
--
作者：
CARPENTER, S;KARPATI, G;WATTERS, G
The childhood type of dermatomyositis which occurs in children and young adults shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. EM discloses undulating tubules in endothelial cells, lymphocytes, pericytes and pseudosatellite cells. The muscle fiber damage is coextensive with capillary damage and probably results from progressive ischemia. The muscle cells, before atrophying, show mitochondrial elongation, Z disk streaming, focal myofibrillary loss and occasionally selective thick filament loss. Muscle cell necrosis is rare and limited to infarctlike lesions. Inflammatory infiltrates, if present, occur only in connective tissue septa. The cause of the capillary damage has not been determined.
