Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction.
Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction.
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DOI：
10.3109/07853890.2010.538080
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发表时间：
2011-02
影响因子：
4.4
通讯作者：
van Veldhuisen DJ
中科院分区：
文献类型：
--
作者：
de Boer RA;Lok DJ;Jaarsma T;van der Meer P;Voors AA;Hillege HL;van Veldhuisen DJ
半乳糖凝集素-3是一种新兴的生物标志物，已在相对较小的心力衰竭（HF）队列（主要为收缩期HF）中进行了研究。我们研究了基线半乳糖凝集素-3在一个大型HF队列中的预后价值，左心室射血分数（LVEF）保持和降低，并将其与其他生物标志物进行比较。我们研究了592名因HF住院的HF患者，并随访了18个月。主要终点是全因死亡率和HF住院率的复合终点。半乳糖凝集素-3水平加倍与主要结局的风险比（HR）为1.97（1.62-2.42）相关（P < 0.001）。校正年龄、性别、BNP、eGFR和糖尿病后，HR为1.38（1.07-1.78; P = 0.015）。Galectin-3水平与IL-6、CRP水平呈正相关（P < 0.002）。6个月后半乳糖凝集素-3水平的变化没有将预后信息添加到基线值（n = 291）;然而，结合血浆半乳糖凝集素-3和BNP水平比单独的任一生物标志物增加了预后值（RoC分析，P < 0.05）。与LVEF降低的患者相比，半乳糖凝集素-3在LVEF保留的患者（n = 114）中的预测价值更强（P < 0.001）。半乳糖凝集素-3是心力衰竭预后的独立标志物，在LVEF保留的心力衰竭患者中特别有用。
Galectin-3 is an emerging biomarker which has been studied in relatively small heart failure (HF) cohorts with predominantly systolic HF. We studied the prognostic value of base-line galectin-3 in a large HF cohort, with preserved and reduced left ventricular ejection fraction (lvef), and compared this to other biomarkers. We studied 592 HF patients who had been hospitalized for HF and were followed for 18 months. The primary end-point was a composite of all-cause mortality and HF hospitalization. A doubling of galectin-3 levels was associated with a hazard ratio (HR) of 1.97 (1.62–2.42) for the primary outcome (P < 0.001). After correction for age, gender, BNP, eGFR, and diabetes the HR was 1.38 (1.07–1.78; P = 0.015). Galectin-3 levels were correlated with higher il-6 and CRP levels (P < 0.002). Changes of galectin-3 levels after 6 months did not add prognostic information to the base-line value (n = 291); however, combining plasma galectin-3 and BNP levels increased prognostic value over either biomarker alone (RoC analysis, P < 0.05). The predictive value of galectin-3 was stronger in patients with preserved LVEF (n = 114) compared to patients with reduced LVEF (P < 0.001). Galectin-3 is an independent marker for outcome in HF and appears to be particularly useful in HF patients with preserved LVEF.
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