Tumor microsatellite instability in early onset gastric cancer
Tumor microsatellite instability in early onset gastric cancer
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DOI：
10.1016/s1525-1578(10)60577-6
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发表时间：
2005-10-01
影响因子：
4.1
通讯作者：
Gallinger, S
中科院分区：
文献类型：
--
作者：
Bacani, J;Zwingerman, R;Gallinger, S
胃癌（GC）仍然是世界范围内癌症死亡的主要原因。遗传因素包括DNA错配修复（MMR）缺陷，表现为肿瘤微卫星不稳定性（MSI）。然而，缺乏标准化的标记面板和CC中低水平与高水平MSI的定义。我们研究了一个以人群为基础的早发(
Gastric cancer (GC) remains a leading cause of cancer mortality worldwide. Genetic factors are implicated, including DNA mismatch repair (MMR) deficiency manifested as tumor microsatellite instability (MSI). However, a standardized panel of markers and a definition of low-versus-high level MSI in CC are lacking. We examined a population-based cohort of early onset (