Epithelial-Mesenchymal Transition: Clinical Implications for Nodal Metastasis and Prognosis of Tongue Cancer
Epithelial-Mesenchymal Transition: Clinical Implications for Nodal Metastasis and Prognosis of Tongue Cancer
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DOI：
10.1177/0194599814556061
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发表时间：
2015-01-01
影响因子：
3.4
通讯作者：
Kim, Sang Yoon
中科院分区：
文献类型：
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作者：
Han, Myung Woul;Lee, Jong Cheol;Kim, Sang Yoon
目的研究舌癌淋巴结转移及预后的生物学标志物对舌癌治疗方案的选择具有重要意义。我们的研究的目的是探讨上皮间质转化（EMT）表达在舌癌中的临床意义。研究设计历史队列研究设置三级护理hospital.Subjects和方法该研究包括95例舌癌患者接受广泛切除和颈淋巴结清扫术。根据E-cadherin和vimentin的免疫组化染色特点，我们将肿瘤分为完全EMT表型、不完全EMT表型和上皮表型。结果46例（48.4%）患者检测到阳性淋巴结，多因素分析显示，阳性淋巴结与浸润深度4 mm和EMT表达显著相关（P = 0.030，P = 0.022）。所有患者的平均随访期为96.3个月（范围，6-149个月）。总体5年DFS为61.7%。多因素分析显示，影响DFS的因素仅为淋巴结分期和EMT表达（P = .033，P = .021）。结论EMT表达是预测舌癌淋巴结转移和肿瘤复发的重要生物学指标。评估EMT在舌癌中的表达可以提供相应的治疗。
Objective The development of biomarkers for the prediction of lymph node metastasis and prognosis is critical for deciding the treatment modality of tongue cancer. The purpose of our study is to investigate the clinical implications of epithelial-mesenchymal transition (EMT) expression in tongue cancer.Study Design Historical cohort studySetting Tertiary-care hospital.Subjects and Methods The study included 95 subjects with tongue cancer who underwent wide excision and neck dissection. According to characteristics of immunohistochemical staining for E-cadherin and vimentin, we classified the tumors as complete EMT phenotype, incomplete EMT phenotype, or epithelial phenotype. The correlation between risk factors and nodal metastasis was assessed, and disease-free survival (DFS) was analyzed.Results Positive lymph nodes were detected in 46 (48.4%) patients and was found to correlate significantly with depth of invasion 4 mm and EMT expression on multivariate analysis (P = .030, P = .022, respectively). The mean follow-up period of all patients was 96.3 months (range, 6-149 months). Overall 5-year DFS was 61.7%. On multivariate analysis, the only factors affecting DFS were nodal stage and EMT expression (P = .033, P = .021, respectively).Conclusions Our study reveals that EMT expression is a significant biomarker for predicting lymph node metastasis and tumor recurrence in tongue cancer. Evaluation of EMT expression in tongue cancer can allow therapy to be offered accordingly.