ETHACRYNIC-ACID AND ITS GLUTATHIONE CONJUGATE AS INHIBITORS OF GLUTATHIONE S-TRANSFERASES
ETHACRYNIC-ACID AND ITS GLUTATHIONE CONJUGATE AS INHIBITORS OF GLUTATHIONE S-TRANSFERASES
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DOI：
10.3109/00498259309059418
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发表时间：
1993-08-01
期刊：
影响因子：
1.8
通讯作者：
VANBLADEREN, PJ
中科院分区：
文献类型：
--
作者：
PLOEMEN, JHTM;VANOMMEN, B;VANBLADEREN, PJ
1.利尿药依他尼酸（EA）是大鼠和人谷胱甘肽S-转移酶（GST）的有效可逆抑制剂，α、μ和pi类的I50值（μ M）分别为4.6-6.0、0.3-1.9和3.3-4.8。EA的谷胱甘肽缀合物的可逆抑制对于α和μ类甚至更强，I50值（μ M）为0.8-2.8，
1. The diuretic drug ethacrynic acid (EA) is a potent reversible inhibitor of rat and human glutathione S-transferases (GST), with I50-values (muM) of 4.6-6.0, 0.3-1.9 and 3.3-4.8 for alpha, mu and pi-class, respectively.2. The reversible inhibition by the glutathione conjugate of EA is even stronger for alpha and mu-class, with I50-values (muM) of 0.8-2.8 and