A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegratioxn
A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegratioxn
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钛上的多面涂层决定骨免疫调节和骨/血管生成以改善骨整合
DOI：
10.1016/j.biomaterials.2018.02.010
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发表时间：
2018-04-01
期刊：
影响因子：
14
通讯作者：
Xiao, Yin
中科院分区：
文献类型：
--
作者：
Bai, Long;Du, Zhibin;Xiao, Yin
具有良好的成骨、血管生成和骨免疫调节能力的多面涂层用于硬组织植入物将具有重要价值，因为它可以改善骨整合和减轻假体松动。然而，迄今为止，很少有涂层完全满足这些标准。本文中，我们描述了由纯钛（Ti）的微弧氧化和随后的退火产生的用羟基磷灰石（HA）纳米颗粒装饰的微孔TiO 2涂层。通过改变退火温度，可以同时调整涂层的物理（形态和润湿性）和化学（复合物和结晶度）特性。用微弧氧化（MAO）以650摄氏度的退火温度（MAO-650）产生的涂层表现出许多有利的物理化学性质，例如混合微纳米形态、超亲水性和高度结晶的HA纳米颗粒。体外实验表明，MAO-650涂层不仅支持成骨细胞和内皮细胞的增殖和分化，而且还抑制巨噬细胞的炎症反应，并实现有利的骨免疫调节，以促进骨/血管生成。体内评价反映了这些结果，并表明与原始MAO涂层相比，MAO-650涂层可改善骨整合。这些数据突出了表面物理化学性质对骨/血管生成调节和骨免疫调节在增强骨整合中的深远影响。皇冠版权所有（C）2018由爱思唯尔有限公司发布。保留所有权利。
A multifaceted coating for hard tissue implants, with favorable osteogenesis, angiogenesis, and osteoimmunomodulation abilities, would be of great value since it could improve osseointegration and alleviate prosthesis loosening. However, to date there are few coatings that fully satisfy these criteria. Herein we describe a microporous TiO2 coating decorated with hydroxyapatite (HA) nanoparticles that is generated by micro-arc oxidation of pure titanium (Ti) and followed annealing. By altering the annealing temperature, it is possible to simultaneously tune the coating's physical (morphology and wettability) and chemical (composites and crystallinity) properties. A coating produced with micro-arc oxidization (MAO) with an annealing temperature of 650 degrees C (MAO-650) exhibits numerous favorable physicochemical properties, such as hybrid micro-nano morphology, superhydrophilicity, and highly crystalline HA nanoparticles. In vitro experiments reveal that the MAO-650 coating not only supports proliferation and differentiation of both osteoblasts and endothelial cells, but also inhibits the inflammatory response of macrophages and enables a favorable osteoimmunomodulation to facilitate osteo/angio-genesis. In vivo evaluation mirrors these results, and shows that the MAO-650 coating results in ameliorative osseointegration when compared with the pristine MAO coating. These data highlight the profound effect of surface physicochemical properties on the regulation of osteo/angio-genesis and osteoimmunomodulation in the enhancement of osseointegration. Crown Copyright (C) 2018 Published by Elsevier Ltd. All rights reserved.