Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles
Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles
复制标题
使用光控偶氮吡唑对 CRAC 通道进行光学控制
DOI：
10.1021/jacs.0c02949
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发表时间：
2020-05-20
影响因子：
15
通讯作者：
Li，Minyong
中科院分区：
文献类型：
--
作者：
Yang，Xingye;Ma，Guolin;Li，Minyong
The Ca2+release-activated Ca2+(CRAC) channels control many Ca2+-modulated physiological processes in mammals. Hyperactivating CRAC channels are known to cause several human diseases, including Stormorken syndrome. Here, we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designatedpiCRACs), which enable optical inhibition of store-operated Ca2+influx and downstream signaling. Moreover,piCRAC-1has been appliedin vivoto alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.
