Gluten-sensitive diarrhea without evidence of celiac disease.
Gluten-sensitive diarrhea without evidence of celiac disease.
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无乳糜泻证据的麸质敏感性腹泻。
DOI：
10.1016/0016-5085(80)90432-1
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发表时间：
1980
期刊：
影响因子：
29.4
通讯作者：
W. Cooke
中科院分区：
文献类型：
--
作者：
B. Cooper;G. Holmes;R. Ferguson;R. Thompson;R. Allan;W. Cooke
八名患有腹痛和慢性腹泻的成年女性患者，经常使人丧失能力，经常在夜间出现，在无麸质饮食和麸质挑战后症状复发后得到了显着缓解。以前的非特异性措施和无奶饮食无效。多个空肠活组织检查显示细胞结构轻微但显著的变化，在无麸质饮食中恢复正常。除了空肠细胞结构略有增加外，谷蛋白激发后未发现免疫学异常。没有发现乳糜泻中常见的脂肪泻或其他生化缺陷。得出的结论是，这些患者患有麸质敏感性腹泻，但没有乳糜泻的证据。
Eight adult female patients suffering from abdominal pain and chronic diarrhea which was often incapacitating and frequently nocturnal, had dramatic relief on a gluten-free diet and return of symptoms after gluten challenge. Previous nonspecific measures and a milk-free diet were ineffective. Multiple jejunal biopsies showed minor, but significant changes in cellularity which returned to normal on the gluten-free diet. Apart from a slight increase in jejunal cellularity, no immunological abnormalities were found after gluten challenge. Steatorrhea or other biochemical defects, common in celiac disease, were not found. It was concluded that these patients had a gluten-sensitive diarrhea, but had no evidence of celiac disease.