Epidemiological analysis of the association between hearing and barium in humans
Epidemiological analysis of the association between hearing and barium in humans
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DOI：
10.1038/jes.2015.62
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发表时间：
2016-09-01
影响因子：
4.5
通讯作者：
Kato, Masashi
中科院分区：
文献类型：
--
作者：
Ohgami, Nobutaka;Mitsumatsu, Yuji;Kato, Masashi
我们之前的实验研究证实了钡（Ba）介导的小鼠听力损失。然而，据我们所知，Ba是否会影响人类的听力仍然未知。本流行病学研究旨在调查Ba对人耳毒性。对145名孟加拉国受试者的头发、脚趾甲和尿液中的Ba水平与听力水平（1,4,8和12 kHz）的关系进行了分析。经年龄、性别、身体质量指数（BMI）和吸烟校正后的二元logistic回归分析显示，8 kHz （OR = 4.75; 95% CI: 1.44, 17.68）和12 kHz （OR = 15.48; 95% CI: 4.04, 79.45）时头发中的Ba水平与听力损失有显著相关。在8 kHz （OR = 3.20; 95% CI: 1.35, 7.85）和12 kHz （OR = 3.63; 95% CI: 1.58, 8.55）时，脚趾甲中的Ba水平也与听力损失相关，而尿液样本中的Ba水平与听力之间没有相关性。在以砷水平作为混杂因素调整的模型中，听力损失与头发和脚趾甲中的Ba水平之间存在显著相关性。总之，本研究表明，Ba水平可能是人类听力损失的一个新的危险因素，特别是在8和12 kHz的高频下。
Our previous study experimentally showed barium (Ba)-mediated hearing loss in mice. To our knowledge, however, it remains unknown whether Ba affects hearing in humans. This epidemiological study aimed at investigating ototoxicity of Ba in humans. Associations of Ba levels in hair, toenails and urine with hearing levels (1, 4, 8 and 12 kHz) were analyzed in 145 Bangladeshi subjects. Binary logistic regression analysis with adjustment for age, sex, body mass index (BMI) and smoking showed that Ba levels in hair had significant associations with hearing loss at 8 kHz (OR = 4.75; 95% CI: 1.44, 17.68) and 12 kHz (OR = 15.48; 95% CI: 4.04, 79.45). Ba levels in toenails were also associated with hearing loss at 8 kHz (OR = 3.20; 95% CI: 1.35, 7.85) and 12 kHz (OR = 3.63; 95% CI: 1.58, 8.55), whereas there was no correlation between Ba level in urinary samples and hearing. There was a significant correlation between hearing loss and Ba levels in hair and toenails in the model adjusted with arsenic levels as the confounder. In conclusion, this study suggested that Ba levels could be a new risk factor for hearing loss, especially at high frequencies of 8 and 12 kHz, in humans.