Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmission.
Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmission.
复制标题
大鼠缺铁时纹状体腺苷 A(2A) 受体的上调：对运动和皮质纹状体神经传递的影响。
DOI：
10.1016/j.expneurol.2010.04.004
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发表时间：
2010
影响因子：
5.3
通讯作者：
Ferré,Sergi
中科院分区：
文献类型：
--
作者：
Quiroz,César;Pearson,Virginia;Gulyani,Seema;Allen,Richard;Earley,Christopher;Ferré,Sergi
Brain iron deficiency leads to altered dopaminergic function in experimental animals, which can provide a mechanistic explanation for iron deficiency-related human sensory-motor disorders, such as Restless Legs Syndrome (RLS). However, mechanisms linking both conditions have not been determined. Considering the strong modulation exerted by adenosine on dopamine signaling, one connection could involve changes in adenosine receptor expression or function. In the striatum, presynaptic A2Areceptors are localized in glutamatergic terminals contacting GABAergic dynorphinergic neurons and their function can be analyzed by the ability of A2Areceptor antagonists to block the motor output induced by cortical electrical stimulation. Postsynaptic A2Areceptors are localized in the dendritic field of GABAergic enkephalinergic neurons and their function can be analyzed by studying the ability of A2Areceptor antagonists to produce locomotor activity and to counteract striatal ERK1/2 phosphorylation induced by cortical electrical stimulation. Increased density of striatal A2Areceptors was found in rats fed during 3weeks with an iron-deficient diet during the post-weaning period. In iron-deficient rats, the selective A2Areceptor antagonist MSX-3, at doses of 1 and 3mg/kg, was more effective at blocking motor output induced by cortical electrical stimulation (presynaptic A2Areceptor-mediated effect) and at enhancing locomotor activation and blocking striatal ERK phosphorylation induced by cortical electrical stimulation (postsynaptic A2Areceptor-mediated effects). These results indicate that brain iron deficiency induces a functional up-regulation of both striatal pre- and postsynaptic A2Areceptor, which could be involved in sensory-motor disorders associated with iron deficiency such as RLS.
