Genetic determinants of depression: recent findings and future directions.
Genetic determinants of depression: recent findings and future directions.
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DOI：
10.1097/hrp.0000000000000054
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发表时间：
2015-01
影响因子：
3.8
通讯作者：
Smoller JW
中科院分区：
文献类型：
--
作者：
Dunn EC;Brown RC;Dai Y;Rosand J;Nugent NR;Amstadter AB;Smoller JW
抑郁症是美国最普遍、最致残、最昂贵的心理健康疾病之一。预防抑郁症和告知其临床治疗的一个有希望的途径在于揭示疾病的遗传和环境决定因素以及它们的相互作用（即基因-环境干预; GXE）。这篇综述论文的总体目标是翻译与抑郁症相关的遗传关联和GxE研究的最新发现，特别是对于没有深入了解遗传学或遗传方法的读者。本审查报告分为三个主要部分。在第一部分中，我们总结了目前已知的抑郁症的遗传决定因素，重点是全基因组关联研究（GWAS）的结果。在第二部分中，我们回顾了GxE研究的结果，这些研究旨在同时研究基因和暴露于特定环境或经历在抑郁症病因学中的作用。在第三部分中，我们描述了抑郁症基因发现的挑战和取得进展的有希望的策略。
Depression is one of the most prevalent, disabling, and costly mental health conditions in the United States. One promising avenue for preventing depression and informing its clinical treatment lies in uncovering both the genetic and environmental determinants of the disorder as well as their interaction (i.e. gene-environment intervention; GxE). The overarching goal of this review paper is to translate recent findings from studies of genetic association and GxE related to depression, particularly for readers without in-depth knowledge of genetics or genetic methods. This review is organized into three major sections. In the first section, we summarize what is currently known about the genetic determinants of depression, focusing on findings from genome-wide association studies (GWAS). In the second section, we review findings from studies of GxE, which seek to simultaneously examine the role of genes and exposure to specific environments or experiences in the etiology of depression. In the third section, we describe the challenges to genetic discovery in depression and promising strategies for making progress.