UNCONJUGATED SECONDARY BILE-ACIDS IN THE SERUM OF PATIENTS WITH COLORECTAL ADENOMAS
UNCONJUGATED SECONDARY BILE-ACIDS IN THE SERUM OF PATIENTS WITH COLORECTAL ADENOMAS
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DOI：
10.1136/gut.36.2.268
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发表时间：
1995-02-01
期刊：
影响因子：
24.5
通讯作者：
PAUMGARTNER, G
中科院分区：
文献类型：
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作者：
BAYERDORFFER, E;MANNES, GA;PAUMGARTNER, G
近年来发现血清中脱氧胆酸（deoxcholic acid，DCA）与大肠腺瘤（大肠癌的前体）呈正相关，支持DCA在大肠癌发生中的致病作用假说。这种方法是基于这样的假设，即在结肠中形成的DCA被吸收到门静脉血液中，并表现出恒定的溢出到体循环。为了进一步证实这一假设，本研究调查了腺瘤患者血清中DCA是否在直接源自结肠的未结合部分中更高。结果发现，结直肠腺瘤患者的非结合部分中DCA是对照组的2.8倍（0.89 v0.32 μ mol/l，p < 0.0025），总DCA组分中为1.9倍（1.89 v0.95 μ mol/l，p < 0.0001），结合部分为1.4倍（0.67 v0.47 μ mol/l，p < 0.05）。进一步发现，腺瘤患者的非结合部分中的细菌异构化产物3 β-DCA比对照组高两倍（0.08 v 0.04 μ mol/l，p = 0.27），总异DCA组分中为1.8倍（0.11对0.06 μ mol/l，p < 0.05），和1.5倍的结合异DCA部分（0.03对0.02 μ mol/l，p = 0.68）。数据表明，如前所述，血清DCA浓度与结直肠腺瘤之间的正相关性是由从结肠吸收的DCA部分引起的。这进一步支持了DCA在结直肠癌发生中的致病作用。
A positive association between deoxcholic acid (DCA) in the serum and colorectal adenomas, the precursors of colorectal cancer has recently been found, which supported the hypothesis of a pathogenic role of DCA in colonic carcinogenesis. This approach was based on the hypothesis that DCA formed in the colon is absorbed into the portal venous blood and exhibits a constant spillover to the systemic circulation. To further substantiate this hypothesis this study investigated whether in the serum of adenoma patients DCA was higher in the unconjugated fraction, which originates directly fi om the colon. DCA was found to be 2.8-fold higher in the unconjugated fraction of patients with colorectal adenomas than in controls (0.89 v 0.32 mu mol/l, p < 0.0025), 1.9-fold in the total DCA fraction (1.89 v 0.95 mu mol/l, p < 0.0001), and 1.4-fold in the conjugated fraction (0.67 v 0.47 mu mol/l, p < 0.05). It was further found that the bacterial isomerisation product 3 beta-DCA was twofold higher in the unconjugated fraction of adenoma patients than in controls (0.08 v 0.04 mu mol/l, p = 0.27), 1.8-fold in the total iso-DCA fraction (0.11 v 0.06 mu mol/l, p < 0.05), and 1.5-fold in the conjugated iso-DCA fraction (0.03 v 0.02 mu mol/l, p = 0.68). The data suggest that the positive association between the serum DCA concentration and colorectal adenoma as described previously results from the DCA fraction that is absorbed from the colon. This further supports a pathogenic role of DCA in the carcinogenesis of colorectal cancer.