Inherently radioresistant cells exist in some human tumors.
Inherently radioresistant cells exist in some human tumors.
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一些人类肿瘤中存在固有的抗辐射细胞。
DOI：
10.1073/pnas.82.14.4732
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发表时间：
1985
影响因子：
11.1
通讯作者：
Little,JB
中科院分区：
文献类型：
--
作者：
Weichselbaum,RR;Dahlberg,W;Little,JB
我们研究了 29 种人类肿瘤细胞系在电离辐射处理后指数生长期间的存活情况。 20个肿瘤细胞系的放射敏感性在正常成纤维细胞的范围内。然而，来自放射线无法治愈的肿瘤的 9 种细胞系似乎具有固有的放射抗性。当在平台期培养物中研究修复潜在致命 X 射线损伤的能力时，一些源自放射线无法治愈的肿瘤的肿瘤细胞系在此过程中更有效。这些结果表明，某些人类肿瘤中存在抗辐射和/或修复能力强的细胞，可能是导致 X 射线治疗后未能获得局部控制的原因。
We investigated the survival of 29 human tumor cell lines after treatment with ionizing radiation during exponential growth. The radiosensitivity of 20 tumor cell lines was within the range of normal fibroblasts. However, 9 cell lines derived from radio-incurable tumors appeared inherently radioresistant. When the ability to repair potentially lethal x-ray damage was studied in plateau phase cultures, some tumor cell lines derived from radio-incurable tumors were more efficient in this process. These results indicate that the presence of radioresistant and/or repair-proficient cells, which exist in some human tumors, may be responsible for failure to obtain local control following therapeutic x-ray treatment.