The ansacarbamitocins: Polar ansamitocin derivatives
The ansacarbamitocins: Polar ansamitocin derivatives
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DOI：
10.1021/np070275t
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发表时间：
2007-10-01
影响因子：
5.1
通讯作者：
Graupner, Paul R.
中科院分区：
文献类型：
--
作者：
Snipes, Carl E.;Duebelbeis, Dennis O.;Graupner, Paul R.
安卡巴胺是美登木素生物碱的一个新家族，通常被葡萄糖亚基和两个氨基甲酸酯官能团取代，并且对某些农业真菌病害生物体表现出适度的活性。安沙卡米菌素 A-F (1-6) 均由与安沙菌素相同的大环核心组成，但葡萄糖单元发生变化，而安沙卡米菌素 A1 和 B1 (7, 8) 在 C-4 和 C-5 上还缺少环氧基团。
The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A-F (1-6) all consist of the same macrocyclic core as the ansamitocins, with variation occurring on the glucose unit, while ansacarbamitocins A1 and B1 (7, 8) additionally lack the epoxide group on C-4 and C-5.