Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells.
Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells.
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DOI：
10.1186/1472-6882-6-27
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发表时间：
2006-08-16
影响因子：
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通讯作者：
Clark, W Dennis
中科院分区：
文献类型：
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作者：
Scheck, Adrienne C;Perry, Krya;Clark, W Dennis
背景：黄芩成熟根中富含黄酮类化合物的提取物已被证明对多种癌细胞具有抗增殖作用。我们评估了黄芩根乙醇提取物抑制恶性胶质瘤细胞增殖的能力。方法：从同一患者的原发性和复发性脑肿瘤中提取的细胞系，以及选择对化疗药物1,3-双（2-氯乙基）-1-亚硝基脲（BCNU）耐药的细胞，用于鉴定该提取物单独使用和与BCNU联合使用时的抗增殖作用。结果与讨论：结果表明，黄芩不仅能抑制复发性和耐药脑肿瘤细胞系的细胞生长，而且与BCNU联合使用时，抑制作用增强。结论：本研究结果支持黄芩苷作为多形性胶质母细胞瘤的抗癌药物的疗效，以及作为目前用于治疗原发性和复发性GBMs的化疗药物的潜在辅助治疗。需要进一步研究单个类黄酮单独使用、相互联合使用以及与目前使用的治疗方法联合使用的效果。
BACKGROUND: Flavonoid-rich extracts from the mature roots of Scutellaria baicalensis have been shown to exhibit antiproliferative effects on various cancer cell lines. We assessed the ability of an ethanolic extract of S. baicalensis root to inhibit the proliferation of malignant glioma cells.METHODS: Cell lines derived from primary and recurrent brain tumors from the same patient and cells selected for resistance to the chemotherapeutic agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) were used to identify antiproliferative effects of this extract when used alone and in conjunction with BCNU.RESULTS AND DISCUSSION: Results indicated that Scutellaria baicalensis not only inhibits cellular growth in recurrent and drug resistant brain tumor cell lines, but also demonstrates an increased inhibitory effect when used in conjunction with BCNU.CONCLUSION: The results of this study support the efficacy of S. baicalensis as an anticancer agent for glioblastomas multiforme and a potential adjuvant treatment to current chemotherapeutic agents used in the treatment of both primary and recurrent GBMs. Further studies of the effects of individual flavonoids alone and in combination with each other and with currently used therapies are needed.