Chemokine up-regulation and activated T cell attraction by maturing dendritic cells
Chemokine up-regulation and activated T cell attraction by maturing dendritic cells
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DOI：
10.1126/science.284.5415.819
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发表时间：
1999-04-30
期刊：
影响因子：
56.9
通讯作者：
Cyster, JG
中科院分区：
文献类型：
--
作者：
Tang, HL;Cyster, JG
从接触致敏皮肤迁移的朗格汉斯细胞在成熟为淋巴结树突状细胞（Lymph node dendritic cells，DC）的过程中上调巨噬细胞源性趋化因子（macrophage-derived chemokine，MDC）的表达。在趋化性测定中，成熟的DC比幼稚T细胞更强烈地吸引活化的T细胞。这些研究确定了趋化因子上调作为朗格汉斯细胞成熟程序的一部分，以免疫原性T细胞区DC。活化T细胞的优先募集可能是成熟DC用于促进与抗原特异性T细胞相遇的机制。
Langerhans' cells migrating from contact-sensitized skin were found to upregulate expression of macrophage-derived chemokine (MDC) during maturation into Lymph node dendritic cells (DCs), Naive T cells did not migrate toward MDC, but antigen-specific T cells rapidly acquired MDC responsiveness in vivo after a subcutaneous injection of antigen. In chemotaxis assays, maturing DCs attracted activated T cells more strongly than naive T cells. These studies identified chemokine up-regulation as part of the Langerhans' cell maturation program to immunogenic T cell-zone DC. Preferential recruitment of activated T cells may be a mechanism used by maturing DCs to promote encounters with antigen-specific T cells.