Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease
Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease
复制标题
患有 HTLV-I 相关神经系统疾病的患者中对 HTLV-I pX 具有特异性的循环 CD8 细胞毒性 T 淋巴细胞
作者：
S. Jacobson;H. Shida;D. McFarlin;A. Fauci;S. Koenig
人类嗜T淋巴细胞病毒I型（HTLV-I）是第一种被鉴定的人类逆转录病毒，与成人T细胞白血病和一种称为热带痉挛性下肢轻瘫或HTLV-I相关脊髓病的中枢神经系统慢性进行性疾病相关1 -4。然而，只有1%的HTLV-I感染者会发展为临床疾病5。HTLV-I感染的各种表现可能与个体遗传背景的差异6、HTLV-I变异株的感染（参考文献7）、病毒嗜性的差异8或宿主对病毒的免疫反应有关。尽管对HTLV-I的体液应答已被充分表征3，4，9，10，但对人类细胞免疫应答，如细胞毒性T淋巴细胞的产生知之甚少11 -13。在这里，我们报告了高水平的循环HTLV-I特异性细胞毒性T淋巴细胞的HTLV-I相关的神经系统疾病的患者，但不是在HTLV-I血清阳性的个人没有神经系统的参与。这些细胞毒性T淋巴细胞是CD 8+、HLA I类限制性的，并且主要识别在调节区pX中编码的HTLV-I基因产物。这些发现表明，HTLV-I特异性细胞毒性T淋巴细胞可能有助于与HTLV-I相关的神经系统疾病的发病机制。
THE human T-lymphotropic virus type I (HTLV-I), the first human retrovirus to be characterized, is associated with adult T-cell leukaemia and a chronic progressive disease of the central nervous system termed tropical spastic paraparesis, or HTLV-I-associated myelopathy1–4. Only 1% of individuals infected with HTLV-I develop clinical disease however5. The various manifestations of an HTLV-I infection may be related to differences in the genetic backgrounds of individuals6, infection with variant strains of HTLV-I (ref. 7), differences in viral tropism8 or host immune response to the virus. Whereas the humoral response to HTLV-I is well characterized3,4,9,10 little is known about the human cellular immune response, such as the production of cytotoxic T lymphocytes11–13. Here we report the presence of high levels of circulating HTLV-I-specific cytotoxic T lymphocytes in patients with HTLV-I associated neurological disease but not in HTLV-I seropositive individuals without neurological involvement. These cytotoxic T lymphocytes are CD8+, HLA class I- restricted and predominantly recognize the HTLV-I gene products encoded in the regulatory region pX. These findings suggest that HTLV-I-specific cytotoxic T lymphocytes may contribute to the pathogenesis of associated neurological disorders associated with HTLV-I.
鼠辅助 T 细胞的人类 T 细胞嗜淋巴细胞病毒 1 型包膜蛋白的免疫显性位点。
DOI：
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发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Kurata,A;Palker,TJ;Streilein,RD;Scearce,RM;Haynes,BF;Berzofsky,JA
通讯作者：
Berzofsky,JA
使用 env 编码的合成肽和 gp46 单克隆抗体绘制人 T 细胞白血病病毒 I 型 (HTLV-I) gp46 和 gp21 包膜糖蛋白的免疫原性区域。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Palker,TJ;Tanner,ME;Scearce,RM;Streilein,RD;Clark,ME;Haynes,BF
通讯作者：
Haynes,BF