Inverted replication of vertebrate mitochondria
Inverted replication of vertebrate mitochondria
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DOI：
10.1093/molbev/msn050
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发表时间：
2008-05-01
影响因子：
10.7
通讯作者：
Harris, D. James
中科院分区：
文献类型：
--
作者：
Fonseca, Miguel M.;Posada, David;Harris, D. James
在分析脊椎动物线粒体编码区碱基组成的不对称性后，我们确定了2种鱼类，白姑鱼和Bathygadus antrodes，具有倒置的组成模式。这两个物种似乎都有一个不寻常的控制区（CR），在B。在阳极上，它已经从轻链切换到重链。据我们所知，这是第一次报告在脊椎动物的逆转线粒体复制，引起的反转的CR。这些发现支持mtDNA复制的链不对称模型，并表明脊椎动物mtDNA可以耐受全局逆转的突变压力。此外，我们建议，核苷酸的偏见是不是链特异性，但它取决于CR的位置。
After analyzing the base composition asymmetry of coding regions in vertebrate mitochondria, we identified 2 fishes, Albula glossodonta and Bathygadus antrodes, with inverted compositional patterns. Both species appear to have an unusual control region ( CR), and in B. antrodes, it has switched from the light strand to the heavy strand. To our knowledge, this is the first report in vertebrates of inverted mitochondrial replication, caused by an inversion of the CR. These findings support the strand- asymmetric model of mtDNA replication and suggest that vertebrate mtDNA can tolerate globally reversed mutational pressures. In addition, we propose that nucleotide bias is not strand specific but that it depends on the location of the CR.