Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens.
Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens.
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血红蛋白 S 和 C 杂合性既不会增强抗体对多种恶性疟原虫抗原的反应的程度，也不会增强抗体反应的广度。
DOI：
10.1093/infdis/jir638
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Crompton,PeterD
中科院分区：
文献类型：
--
作者：
Tan,Xiaolin;Traore,Boubacar;Kayentao,Kassoum;Ongoiba,Aissata;Doumbo,Safiatou;Waisberg,Michael;Doumbo,OgobaraK;Felgner,PhilipL;Fairhurst,RickM;Crompton,PeterD
(See the editorial commentary by Williams, on pages 1651–3.)Background.Heterozygous states of hemoglobin (Hb) A and HbS (HbAS, sickle-cell trait) or HbC (HbAC) protect againstPlasmodium falciparummalaria by unclear mechanisms. Several studies suggest that HbAS and HbAC accelerate the acquisition of immunity to malaria, possibly by enhancingP. falciparum–specific antibody responses.Methods.We used a protein microarray representing 491P. falciparumproteins expressed during exoerythrocytic and erythrocytic stages of the life cycle to test the hypothesis that HbAS and HbAC enhance theP. falciparum–specific IgG response compared with normal HbAA. Plasma samples were collected from Malian children aged 2–10 years before and after a 6-month malaria season and were probed against the microarray. Immunoglobulin G (IgG) profiles of children with HbAA (n = 106), HbAS (n = 15), and HbAC (n = 20) were compared.Results.Although the magnitude and breadth ofP. falciparum–specific IgG responses increased with age and from before to after the malaria season in each antigen category, Hb type did not independently predict significant differences inP. falciparum–specific IgG profiles.Conclusions.These data do not support the hypothesis that HbAS and HbAC protect against malaria by enhancingP. falciparum–specific antibody responses. It remains possible that HbAS and HbAC protect against malaria by enhancing antibody responses to antigens not studied here or through other immune mechanisms.
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DOI：
--
发表时间：
2006
期刊：
総務省統計研修所 リサーチペーパー 第5号
影响因子：
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DOI：
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发表时间：
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