The effect of age of disease onset on neuropsychological performance in Parkinson's disease.
The effect of age of disease onset on neuropsychological performance in Parkinson's disease.
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发病年龄对帕金森病神经心理学表现的影响。
DOI：
10.1136/jnnp.51.2.244
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
H. Teräväinen
中科院分区：
文献类型：
--
作者：
M. Hietanen;H. Teräväinen
对108例非住院帕金森氏病患者进行了研究，以了解发病年龄是否影响患者的认知、记忆和精神运动表现。与年龄匹配的正常受试者相比，“早发性”患者(其疾病开始于60岁之前)在神经心理表现方面表现出广泛的损害。然而，根据DSM III标准，这些患者中只有1人(2%)患有痴呆症。痴呆在病程相同但发病较晚(超过60岁)的患者中更为常见；这类患者中有13人(25%)患有痴呆症。目前的研究支持了先前的研究结果，即帕金森氏症患者的痴呆症随着年龄的增长而增加。它还表明，在早期发病的患者中也发现了认知变化。
One hundred and eight noninstitutionalized patients with Parkinson's disease were studied to find out whether the age of disease onset affects patients' cognitive, memory and psychomotor performance. "Early onset" patients (whose disease began before 60 years of age) showed a wide spectrum of impairments in neuropsychological performance compared with age-matched normal subjects. However, only one (2%) of these patients was demented according to DSM III criteria. Dementia was more frequent in patients with equivalent disease duration, but with late onset of disease (over 60 years); 13 of such patients (25%) were demented. The present study supports previous findings which show that dementia increases with advancing age in Parkinson's disease. It also suggests that cognitive changes are also found in patients with early onset of disease.