Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK-MB accuracy
Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK-MB accuracy
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DOI：
10.1016/j.metabol.2017.05.002
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发表时间：
2017-08-01
影响因子：
9.8
通讯作者：
Mantzoros, Christos S.
中科院分区：
文献类型：
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作者：
Anastasilakis, Athanasios D.;Koulaxis, Dimitrios;Mantzoros, Christos S.
背景。心肌会产生几种肌因子。与对照组相比，我们研究了急性心肌梗死（MI）时和再灌注后肌因子水平的变化。将经皮冠状动脉介入治疗（PCI）的心肌梗死患者（MI组，n = 31）与经皮冠状动脉介入治疗（CAD组，n = 40）的稳定性冠状动脉疾病（CAD）患者（CAD组，n = 40）和无血管造影狭窄的模拟CAD症状的对照组（对照组，n = 43）进行比较。记录狭窄的数量和程度。测定鸢尾素、卵泡抑素、卵泡抑素样3、激活素A和B、ALT、AST、CK和CK- mb在基线和干预后6或24 h。心肌梗死和冠心病患者的鸢尾素水平低于对照组（p < 0.001）。心肌梗死患者的卵泡抑素、激活素A、CK、CK- mb和AST均高于冠心病患者和对照组（均p < 0.001）。再灌注后没有任何肌因子改变。循环鸢尾素与所有患者狭窄程度相关（p = 0.05）。鸢尾素预测心肌梗死的准确性不低于CK-MB，而folistatin和activin A可以区分心肌梗死和CAD患者，其准确性与CK-MB相似。与ck - mb相比，PCI术后这些肌因子均未发生改变。心肌梗死和冠心病患者的鸢尾素水平较低，这意味着它们的产生可能依赖于心肌血液供应。心肌梗死患者的卵泡抑素和激活素A高于冠心病患者，表明心肌坏死导致释放增加。它们预测心肌梗死的准确性与CK-MB相似，其在心肌梗死诊断中的作用有待于前瞻性大型临床研究的证实。(C) 2017爱思唯尔公司版权所有。
Background. Several myokines are produced by cardiac muscle. We investigated changes in myokine levels at the time of acute myocardial infarction (MI) and following reperfusion in relation to controls.Methods. Patients with MI (MI Group, n = 31) treated with percutaneous coronary intervention (PCI) were compared to patients with stable coronary artery disease (CAD) subjected to scheduled PCI (CAD Group, n = 40) and controls with symptoms mimicking CAD without stenosis in angiography (Control Group, n = 43). The number and degree of stenosis were recorded. Irisin, follistatin, follistatin-like 3, activin A and B, ALT, AST, CK and CK-MB were measured at baseline and 6 or 24 h after the intervention.Results. MI and CAD patients had lower irisin than controls (p < 0.001). MI patients had higher follistatin, activin A, CK, CK-MB and AST than CAD patients and controls (all p < 0.001). None of the myokines changed following reperfusion. Circulating irisin was associated with the degree of stenosis in all patients (p = 0.05). Irisin was not inferior to CK-MB in predicting MI while folistatin and activin A could discriminate MI from CAD patients with similar to CK-MB accuracy. None of these myokines was altered following PCI in contrast to CK-MB.Conclusions. Irisin levels are lower in MI and CAD implying that their production may depend on myocadial blood supply. Follistatin and activin A are higher in MI than in CAD suggesting increased release due to myocardial necrosis. They can predict MI with accuracy similar to CK-MB and their role in the diagnosis of MI remains to be confirmed by prospective large clinical studies. (C) 2017 Elsevier Inc. All rights reserved.