Intravesical potassium sensitivity in patients with interstitial cystitis and urethral syndrome
Intravesical potassium sensitivity in patients with interstitial cystitis and urethral syndrome
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DOI：
10.1016/s0090-4295(00)01110-9
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发表时间：
2001-03-01
期刊：
影响因子：
2.1
通讯作者：
Parsons, JK
中科院分区：
文献类型：
--
作者：
Parsons, CL;Zupkas, P;Parsons, JK
目标。采用钾敏感性试验（PST）对临床诊断为间质性膀胱炎（IC）和尿道综合征的人群和正常对照组进行检查，以确定PST引起的疼痛和/或尿急的发生率，并记录IC和尿道综合征疼痛的类型和部位、疼痛与性交的关系以及女性尿急/尿频问题的家族史。方法：对临床IC患者466例、尿道综合征患者116例、对照组42例进行PST和问卷调查。78%的临床IC患者PST阳性，55%的尿道综合征患者PST阳性，对照组PST阳性的比例为0%。在临床IC患者中，9%的患者仅对疼痛有反应，8%的患者仅对急症有反应。临床IC患者报告的疼痛为排尿困难（58%）、尿道/阴道（76%）、耻骨以上（53%）、下腹部（47%）、下背部（35%）、阴道（51%）和腹股沟（28%）。尿道综合征患者的结果相似。在性活跃的男性和女性中，71%的临床IC和59%的尿道综合征患者报告性交时疼痛。35%的IC患者和33%的尿道综合征患者报告了女性亲属的急症/尿频问题。临床IC患者和尿道综合征患者均有明显的钾敏感性，而正常对照则没有钾敏感性，这表明PST阳性提示存在异常膀胱上皮。尿道综合征患者PSTs阳性率较低，反映了尿道综合征（早期IC）症状较轻、间歇性较强。膀胱源性骨盆疼痛可发生在骨盆的任何部位。最后，IC似乎有遗传成分。中华泌尿外科杂志（英文版），2001。(C) 2001, Elsevier Science Inc.；
Objectives. To examine populations with diagnosed clinical interstitial cystitis (IC) and urethral syndrome and normal controls using the potassium sensitivity test (PST), to determine the incidence of PST-provoked pain and/or urgency, and to document the type and location of IC and urethral syndrome pain, association of pain with sexual intercourse, and family history of female urgency/frequency problems.Methods, The PST and a questionnaire were administered to 466 patients with clinical IC, 116 patients with urethral syndrome, and 42 controls.Results. The PST was positive in 78% of patients with clinical IC, in 55% of patients with urethral syndrome, and in 0% of the controls. Of the patients with clinical IC, 9% responded to the PST with pain only and 8% with urgency only. Patients with clinical IC reported the pain as dysuria (58%), urethral/vaginal (76%), above the pubic bone (53%), lower abdomen (47%), lower back (35%), vaginal (51%), and inguinal (28%). The results were similar for patients with urethral syndrome. Of the sexually active men and women, 71% with clinical IC and 59% with urethral syndrome reported pain associated with intercourse. Urgency/frequency problems in female relatives were reported by 35% of patients with IC and 33% of those with urethral syndrome.Conclusions. The significant potassium sensitivity in both patients with clinical IC and those with urethral syndrome and the absence of potassium sensitivity in normal controls indicates that a positive PST suggests the presence of an abnormal bladder epithelium. The lower rate of positive PSTs in patients with urethral syndrome reflects the less severe, more intermittent, nature of the symptoms in urethral syndrome (early IC). Pelvic pain of bladder origin may occur anywhere in the pelvis. Finally, IC appears to have a genetic component. UROLOGY 57: 428-433, 2001. (C) 2001, Elsevier Science Inc.