Small cell carcinoma of the gallbladder: a case report and review of 53 cases in the literature.
Small cell carcinoma of the gallbladder: a case report and review of 53 cases in the literature.
复制标题
胆囊小细胞癌53例病例报告及文献复习.
作者：
H. Fujii;T. Aotake;T. Horiuchi;Y. Chiba;Y. Imamura;K. Tanaka
虽然胆囊小细胞癌是罕见的，这种肿瘤类型的预后比分化癌差。我们在此报告的情况下，一个62岁的男子与胆囊小细胞癌。手术结果显示一个无法切除的胆囊大肿瘤，并有肝脏及淋巴结的多处转移。病理结果显示癌细胞体积小，呈圆形或椭圆形，呈索状或实性。诊断证实了超微结构研究，显示存在神经分泌型核心颗粒。患者接受顺铂和依托泊苷动脉化疗。六个月后，腹部计算机断层扫描证实大肿块消失。在六个月的时间内观察到对化疗的完全反应，表明动脉内化疗对这种疾病的疗效。本文回顾了53例小细胞癌的英文文献。在大多数情况下，包括我们的，没有根治性手术的指示和预后极差，由于早期诊断的困难和疾病的快速进展。化疗是有效的一般和动脉化疗进行在这种情况下可能是特别有用的，以提高生存。
Although small cell carcinoma of the gallbladder is rare, the prognosis of this tumor type is poorer than that of differentiated carcinomas. We report herein the case of a 62-year-old man with small cell carcinoma of the gallbladder. The operative findings showed an unresectable large tumor of the gallbladder and multiple metastases involving the liver and lymph nodes. Pathological findings revealed small sized carcinoma cells, round or oval in shape which displayed a cord-like or solid appearance. Diagnosis was confirmed by ultrastructural study that showed the presence of neurosecretory-type cored granules. He was treated by intraarterial chemotherapy with cisplatin and etoposide. Six months later, abdominal computed tomography scan confirmed loss of the large mass. A complete response to the chemotherapy was noted over a period of six months, suggesting the efficacy of intraarterial chemotherapy for this disease. Fifty-three cases of small cell carcinoma reported in the English literature are reviewed. In most cases, including ours, a radical operation was not indicated and the prognosis was extremely poor, due to the difficulty of early diagnosis and the rapid progression of the disease. Chemotherapy is effective in general and intraarterial chemotherapy performed in the present case may be particularly useful to improve survival.