HONEY AND OTHER ENVIRONMENTAL RISK-FACTORS FOR INFANT BOTULISM
HONEY AND OTHER ENVIRONMENTAL RISK-FACTORS FOR INFANT BOTULISM
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DOI：
10.1016/s0022-3476(79)80863-x
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发表时间：
1979-01-01
影响因子：
5.1
通讯作者：
CHIN, J
中科院分区：
文献类型：
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作者：
ARNON, SS;MIDURA, TF;CHIN, J
婴儿肉毒杆菌中毒是肉毒杆菌在婴儿S肠道定植后体内产生毒素所致。对这种新近发现的疾病进行了流行病学和实验室调查，以确定危险因素和肉毒杆菌孢子可能到达易感婴儿的途径。在6个不同的蜂蜜样本中鉴定出肉毒杆菌，但没有预制毒素，这些蜂蜜样本喂给了3名美国加州的婴儿肉毒杆菌中毒患者和10%(9/90)的蜂蜜样本。根据食物接触史，蜂蜜与B型婴儿肉毒杆菌中毒显著相关(P=0.005)。在加利福尼亚州，29.2%(12/41)的住院患者在便秘发作之前服用了蜂蜜；在世界范围内，34.7%(28/75)的住院患者发生了蜂蜜暴露。在所有检测的食品中，只有蜂蜜含有肉毒杆菌。1份家用吸尘器粉尘样本和5份土壤样本(3份来自病例家庭，2份来自对照家庭)含有肉毒杆菌。已知的肉毒杆菌的普遍分布表明，接触其孢子是普遍的，宿主因素在婴儿肉毒杆菌中毒的发病机制中起着重要作用。蜂蜜现在是肉毒杆菌孢子的可识别和可避免的来源，不应该给婴儿喂食。
Infant botulism results from the in vivo production of toxin by Clostridium botulinum after it colonizes the infant''s gut. Epidemiologic and laboratory investigations of this recently recognized disease were undertaken to identify risk factors and routes by which C. botulinum spores might reach susceptible infants. C. botulinum organisms, but no preformed toxin, were identified in 6 different honey specimens fed to 3 California [USA] patients with infant botulism and from 10% (9/90) of honey specimens studied. By food exposure history, honey was significantly associated with type B infant botulism (P = 0.005). In California, 29.2% (12/41) of hospitalized patients were fed honey prior to onset of constipation; worldwide, honey exposure occurred in 34.7% (28/75) of hospitalized cases. Of all food items tested, only honey contained C. botulinum organisms. One household vacuum cleaner dust specimen and 5 soil specimens (3 from case homes, 2 from control homes) contained C. botulinum. The known ubiquitous distribution of C. botulinum implies that exposure to its spores is universal and that host factors contribute importantly to the pathogenesis of infant botulism. Honey is now an identified and avoidable source of C. botulinum spores, and it should not be fed to infants.