Synthesis and structure of 2-methyl-6-oxo-7,8-dihydrospiro(benzo[h]-triazolo[3,4-b]quinazoline-7,1′-cyclopentane)
Synthesis and structure of 2-methyl-6-oxo-7,8-dihydrospiro(benzo[h]-triazolo[3,4-b]quinazoline-7,1′-cyclopentane)
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2-甲基-6-氧代-7,8-二氢螺(苯并[h]-三唑并[3,4-b]喹唑啉-7,1′-环戊烷)的合成与结构
DOI：
10.1007/bf02290848
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发表时间：
2000
影响因子：
1.5
通讯作者：
Y. Struchkov
中科院分区：
文献类型：
--
作者：
A. Markosyan;R. A. Kuroyan;S. Dilanyan;M. Aleksanyan;A. Karapetyan;Y. Struchkov
4-氨基-3-乙氧羰基-1，2-二氢螺（萘-2，1 ′-环戊烷）与苯甲酰基异硫氰酸酯反应生成相应的4-（N′-苯甲酰基硫脲基）衍生物，再环合生成4-氧代-2-硫代-1，2，3，4，5，6-六氢螺（苯并[h]喹唑啉-5，1 ′-环戊烷）。后者与水合肼缩合得到2-肼基-3，4，5，6-四氢螺（苯并[h]喹唑啉-5，1 ′-环戊烷），再与原甲酸酯反应得到6-氧代-1H-7，8-二氢螺（苯并[h]三唑并[3，4-B]喹唑啉-7，1 ′-环戊烷）。产物用碘甲烷甲基化得到其2-甲基衍生物。
The reaction of 4-amino-3-ethoxycarbonyl-1,2-dihydrospiro(naphthalene-2,1′-cyclopentane) with benzoyl isothiocyanate led to the corresponding 4-(N′-benzoylthioureido) derivative, the cyclization of which gave 4-oxo-2-thioxo-1,2,3,4,5,6-hexahydrospiro(benzo[h]qquinazoline-5,1′-cyclopentane). Condensation of the latter with hydrazine hydrate gave 2-hydrazino-3,4,5,6-tetrahydrospiro(benzo[h] quinazoline-5,1′-cyclopentane), which formed 6-oxo-1H-7,8-dihydrospiro(benzo[h] triazolo[3,4-b] quinazoline7,1′-cyclopentane) in reaction with orthoformice ester. Methylation of the product with methyl iodide led to its 2-methyl derivative.