Myocardial infarction deaths after high level exposure to particulate matter
Myocardial infarction deaths after high level exposure to particulate matter
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DOI：
10.1136/jech.2005.038315
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发表时间：
2006-03-01
影响因子：
6.3
通讯作者：
Ono, M
中科院分区：
文献类型：
--
作者：
Murakami, Y;Ono, M
研究目的：为了研究空气污染物浓度升高对心肌梗死死亡的短期影响，作者测量了悬浮颗粒物（SPM）浓度达到不同临界值后，发病率比率是否增加，并持续不同的时间段。设计：回顾性分析一个数据库，其中包含每小时SPM浓度和心肌梗死死亡。比较SPM类别之间归因于心肌梗死的死亡率（事件/1000小时）。SPM类别分为五个不同的临界值，衡量高SPM水平，并通过小时的曝光主要观察指标：将不同SPM类别中调整后的发病率比与参考类别进行比较，（0-99 μ g/m3），以确定发病率比。地点：日本东京都区。患者/参与者：1990 ~ 1994年东京都地区14950例心肌梗塞死亡者的资料。主要结果：当暴露窗为1h时，各类别的校正发病率比为1.13（95% CI：1.07 - 1.20），中间类别为1.17-1.24，最高（300 mg/m3以上）类别为1.40（1.00 - 1.97）。当暴露窗口为1至6小时时，在最高类别中观察到率比增加（1.17（4小时）至1.40（1小时））。发病率的比例逐渐增加，被视为SPM类别增加时，曝光窗口小于6 hours.Conclusion：心肌梗死死亡率的比例增加后，在几个小时内达到高浓度的SPM。当暴露窗小于6 h时，随着SPM浓度的增加，发病率比值逐渐增加。
Study objective: To examine the short term effects of raised concentrations of air pollutants on myocardial infarction deaths, the authors measured if incidence rate ratios increased after the concentration of suspended particulate matter (SPM) reached various critical values and were sustained for various periods of time.Design: Retrospective analysis of a database, which contained hourly SPM concentrations and myocardial infarction deaths.Methods: The rate of death (events/1000 hours) attributable to myocardial infarction was compared among SPM categories. SPM categories were classified by five different critical values that measured high SPM levels, and by the hours of exposure (exposure window) after reaching the critical SPM level.Main outcome measures: The adjusted incidence rate ratios in the various SPM categories were compared with the reference category (0-99 mu g/m(3)) to determine the incidence rate ratio.Setting: Tokyo Metropolitan area, Japan.Patients/participants: 14 950 people who died of myocardial infarction in the Tokyo Metropolitan area from 1990 to 1994.Main results: When the exposure window was one hour, the adjusted incidence rate ratio in each category were 1.13 (95% CI: 1.07 to 1.20) in the 100-149 mg/m(3) category, 1.17-1.24 in the intermediate categories, and 1.40 (1.00 to 1.97) in the highest (300 mg/m(3) over) category. When the exposure window was one to six hours, increased rate ratios were seen in the highest category (1.17 (four hours) to 1.40 (one hour)). Gradual increases in the incidence rate ratio were seen as the SPM category increased when the exposure window was less than six hours.Conclusion: An increased rate ratio of myocardial infarction deaths was seen within a few hours after reaching a high concentration of SPM. When the exposure window was less than six hours, there was a gradual increase in the incidence rate ratio as the SPM concentration increased.