Dependence of impaired eye tracking on deficient velocity discrimination in schizophrenia
Dependence of impaired eye tracking on deficient velocity discrimination in schizophrenia
复制标题
DOI：
10.1001/archpsyc.56.2.155
复制
发表时间：
1999-02-01
影响因子：
--
通讯作者：
Holzman, PS
中科院分区：
文献类型：
--
作者：
Chen, Y;Levy, DL;Holzman, PS
背景：许多精神分裂症患者及其约40%的一级亲缘患者存在异常的顺行追踪眼球运动。精神分裂症患者也表现出速度辨别缺陷。由于负责处理速度信号的大脑区域参与了平稳追踪的产生和维持，因此，本研究探讨了速度辨别力缺陷与平滑追踪眼动受损之间的关系。方法：记录15例精神分裂症患者和8名正常人对正弦波(可预测)和阶跃坡度(不可预测)目标的水平眼动。顺畅的追踪眼球运动在开始和维持期间都被评估。结果：精细速度辨别的对比敏感度与平滑追踪的初始加速度和峰值增益显著相关，而与扫视频率和追踪完整性的定性评分无显著相关。结论：速度信息加工不足可能是精神分裂症患者顺畅追踪启动和维持功能障碍的原因之一。
Background: Abnormal smooth pursuit eye movements have been found in many schizophrenic patients and in about 40% of their first-degree biological relatives. A velocity discrimination deficit has also been demonstrated in schizophrenic patients. In this study, we address the relation between deficient velocity discrimination and impaired smooth pursuit eye movements, inasmuch as the brain regions responsible for processing velocity signals are implicated in generating and maintaining smooth pursuit.Methods: Horizontal eye movements of 15 schizophrenic patients and 8 normal controls were recorded in response to sine wave (predictable) and step-ramp (nonpredictable) targets. Smooth pursuit eye movements were assessed during both the initiation and maintenance periods. Correlations were computed between measures of smooth pursuit (qualitative rating, peak gain, saccade frequency, and initial acceleration) and contrast sensitivity for velocity discrimination.Results: Contrast sensitivity for fine velocity discrimination was significantly correlated both with initial acceleration of smooth pursuit and with peak gain, but was not significantly correlated with saccade frequency and qualitative ratings of pursuit integrity. No significant correlations were found within the normal control group.Conclusion: Deficient processing of velocity information seems to be one component that contributes to a dysfunction in the initiation and maintenance of smooth pursuit in schizophrenia.