3D surface imaging for monitoring intrafraction motion in frameless stereotactic body radiotherapy of lung cancer
3D surface imaging for monitoring intrafraction motion in frameless stereotactic body radiotherapy of lung cancer
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DOI：
10.1016/j.radonc.2012.08.016
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发表时间：
2012-11-01
影响因子：
5.7
通讯作者：
Remeijer, Peter
中科院分区：
文献类型：
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作者：
Alderliesten, Tanja;Sonke, Jan-Jakob;Remeijer, Peter
目的：通过与锥束计算机断层扫描（CBCT）的比较，探讨表面成像在肺癌无框架立体定向放射治疗（SBRT）中监测病灶内运动的准确性。材料与方法：纳入36例患者，男18例，女18例。在每个分数中，采集三次CBCT扫描；CBCT1：治疗前，CBCT2：肿瘤错位矫正后，CBCT3：治疗后。通过将CBCT2和CBCT3登记到中期通气计划CT扫描中，推导出抽吸内运动。表面捕获与CBCT采集同时进行。回顾性地，对于每一组表面，创建一个平均表面：Surface1， Surface2和Surface3。随后，将Surface3注册到Surface2，以评估引力内运动。对于基于CBCT和基于表面成像的三维屈光度运动的差异，我们计算了组均值、系统误差、随机误差和一致限（LOA）。结果：女性的组平均误差、系统误差和随机误差均小于男性：分别为0.4 vs. 1.3、1.3 vs. 3.1和1.7 vs. 3.3 mm。对于女性患者，cbct -肿瘤和3d表面成像衍生的内缩运动之间的偏差在-3.3和4.3 mm之间（95% LOA）。结论：表面成像技术在女性患者的SBRT中是一种很有前途的技术，可用于监测眼球内运动。2012爱思唯尔爱尔兰有限公司版权所有。放射治疗与肿瘤学105 (2012):155-160
Purpose: To investigate the accuracy of surface imaging for monitoring intrafraction motion purposes in frameless stereotactic body radiotherapy (SBRT) of lung cancer by comparison with cone-beam computed tomography (CBCT).Materials and methods: Thirty-six patients (18 males, 18 females) were included. During each fraction, three CBCT scans were acquired; CBCT1: before treatment, CBCT2: after correction for tumor misalignment, and CBCT3: after treatment. Intrafraction motion was derived by registering CBCT2 and CBCT3 to the mid-ventilation planning CT scan. Surfaces were captured concurrently with CBCT acquisitions. Retrospectively, for each set of surfaces, an average surface was created: Surface1, Surface2, and Surface3. Subsequently, Surface3 was registered to Surface2 to assess intrafraction motion. For the differences between CBCT- and surface-imaging-derived 3D intrafraction motions, group mean, systematic error, random error and limits of agreement (LOA) were calculated.Results: Group mean, systematic and random errors were smaller for females than for males: 0.4 vs. 1.3, 1.3 vs. 3.1, and 1.7 vs. 3.3 mm respectively. For female patients deviations between CBCT-tumor- and 3D-surface-imaging-derived intrafraction motions were between -3.3 and 4.3 mm (95% LOA). For male patients these were substantially larger: -5.9-9.5 mm.Conclusion: Surface imaging is a promising technology for monitoring intrafraction motion purposes in SBRT for female patients. (C) 2012 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 105 (2012) 155-160