Enantioselective Intermolecular Formal [3+3] Cycloaddition of 2,3-Disubstituted Indoles with Acrolein
Enantioselective Intermolecular Formal [3+3] Cycloaddition of 2,3-Disubstituted Indoles with Acrolein
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2,3-二取代吲哚与丙烯醛的对映选择性分子间缩甲醛[3 3]环加成反应
DOI：
10.1021/ol401809d
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发表时间：
2013-09-06
期刊：
影响因子：
5.2
通讯作者：
Wu, Xiaoyu
中科院分区：
文献类型：
--
作者：
Huang, Jianbiao;Zhao, Long;Wu, Xiaoyu
通过有机催化丙烯醛与2，3-二取代吲哚的[3 + 3]环加成反应，实现了高取代咔唑类化合物的对映选择性合成。由2，3-二取代吲哚和丙烯醛以良好至优异的产率和优异的对映选择性合成了三环氢咔唑。
An expedient enantioselective synthesis of highly substituted hydrocarbazoles has been realized by an organocatalyzed formal [3 + 3] cycloaddition between acrolein and 2,3-disubstituted indoles. Tricyclic hydrocarbazoles were obtained from a broad range of 2,3-disubstituted indoles and acrolein in good to excellent yields and excellent enantioselectivites.